Sensor and method for removing interfering substance

• US 9,271,671 B2
• Filed: 03/28/2011
• Issued: 03/01/2016
• Est. Priority Date: 04/16/2010
• Status: Active Grant

• Current Assignee: ARKRAY, Inc
• Original Assignee: ARKRAY, Inc
• Inventors: Shiraki, Yasunori, Katsuki, Koji, Iketani, Kazuya
• Primary Examiner(s): WEST, PAUL M
• Application Number:
  US13/641,022
• Publication Number:
  US 20130068000A1
• Time in Patent Office: 1,800 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/14735 comprising an immobilised reagent
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6865 Access ports
• CPC Class Codes: C25F 1/00 Electrolytic cleaning, degreasing, pickling or descaling
• CPC Class Codes: G01N 1/34 Purifying; Cleaning processes or apparatus for extracting or separating nucleic acids from biological samples C12N15/1003
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 27/40 Semi-permeable membranes or partitions

Abstract

A technique is provided, wherein any influence, which would be otherwise exerted on a reaction of an objective substance caused by a reagent enzyme by an interfering substance contained in a specimen, is suppressed in relation to an electrochemical sensor for measuring the objective substance contained in the specimen. A sensor comprises a substrate; a detecting unit which is provided on the substrate and which detects an objective substance; a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in a sample on the other hand; and removing unit which removes the interfering substance adhered to the filter.

Claims

1. A sensor for measuring an objective substance contained in a sample, the sensor comprising:

a substrate;

a detecting unit which is provided on the substrate and which detects the objective substance;

a filter which covers the detecting unit, which permits permeation of the objective substance on one hand, and which regulates permeation of an interfering substance contained in the sample on the other hand; and

a removing unit which removes the interfering substance adhered to the filter by supplying to the filter an agent for decomposing the interfering substance,

wherein the removing unit comprises;

a piezoelectric element which is vibrated by applying a voltage;

an accommodating case which accommodates the agent; and

a discharge hole which is formed to be open on the accommodating case, and

wherein the agent is discharged from the discharge hole by transmitting vibrational energy of the piezoelectric element to the accommodating case so that the agent is supplied to the filter.

2. The sensor according to claim 1, wherein the detecting unit is used while being retained subcutaneously.

3. A method for removing an interfering substance, to be applied to a sensor comprising a detecting unit which is provided on a substrate and which detects an objective substance contained in a sample, the method comprising:

allowing the interfering substance to adhere to a filter beforehand by covering the detecting unit with the filter which permits permeation of the objective substance on one hand and which regulates permeation of the interfering substance contained in the sample on the other hand, and removing the interfering substance adhered to the filter by means of a removing unit which removes the interfering substance by supplying to the filter an agent for decomposing the interfering substance,

wherein the removing unit comprises;

a piezoelectric element which is vibrated by applying a voltage;

an accommodating case which accommodates the agent; and

a discharge hole which is formed to be open on the accommodating case; and

wherein the agent is discharged from the discha e hole b transmitting vibrational energy of the piezoelectric element to the accommodating case so that the agent is supplied to the filter.