Carbon dioxide, saline and additional active nasal delivery methods and treatments

• US 9,272,036 B2
• Filed: 04/18/2012
• Issued: 03/01/2016
• Est. Priority Date: 04/18/2012
• Status: Active Grant

• Current Assignee: Clover Hill Healthcare, Inc.
• Original Assignee: Clover Hill Healthcare, Inc.
• Inventors: Glynn, Kenneth P.
• Primary Examiner(s): Mendez, Manuel
• Application Number:
  US13/506,425
• Publication Number:
  US 20130281917A1
• Time in Patent Office: 1,413 Days
• Field of Search: 128/203.14, 128/203.16
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 2202/0225 Carbon oxides, e.g. Carbon dioxide
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2210/0618 Nose
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 35/30 Gas therapy for therapeutic treatment of the skin
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants

Abstract

Methods for treating ailments in a patient in need thereof includes the step of directing a therapeutic, non-inhaled dosage to at least one nasal cavity of the patient through a flow regulating device while the patient refrains from inhaling. The dosage includes (a) a saline fluid (b) a gas containing carbon dioxide and (c) at least one additional active component, wherein the therapeutic, non-inhaled dosage is delivered at a flow rate from 1 cc/sec to 20 cc/sec for a duration of 2 to 30 seconds.

Claims

1. A method for treating head ailments in a patient in need thereof, said method, comprising:

directing a therapeutic, non-inhaled dosage to at least one nasal cavity of said patient through a flow regulating device, said dosage including;

a) a saline fluid, b) a gas containing carbon dioxide and c) at least one additional active component, wherein the therapeutic, non-inhaled dosage is delivered at a flow rate from 1 cc/sec to 5 cc/sec for a duration of 2 to 30 seconds, while said patient is substantially refraining from inhaling and wherein said gaseous carbon dioxide is dissolved in said saline fluid and said at least one additional active component, wherein a pressure-charging moveable component is located on said flow regulating device and wherein the dose may be repeated from 1 to 10 times.

2. The method of claim 1, wherein said treated head ailment is selected from the group consisting of rhinitis, conjunctivitis, common cold and sinusitis.

3. The method of claim 1, wherein said method is treating rhinitis and the rhinitis is allergic rhinitis.

4. The method of claim 1, wherein said method is treating conjunctivitis.

5. The method of claim 1, wherein said method is treating sinusitis.

6. The method of claim 1, wherein said method is treating common cold.

7. The method of claim 1, wherein said head ailment is headache.

8. The method of claim 1, wherein said flow regulating device is a single dose dispenser with a pressure control for released flow regulation.

9. The method of claim 1, wherein said flow regulating device is a multiple dose dispenser with a pressure control for released flow regulation.

10. The method of claim 9, wherein said multiple dose dispenser furthers a dosage amount control mechanism and activator to limit dosage release amount for each activation.

11. The method of claim 1, wherein the duration is 5 to 10 seconds per nasal cavity.

12. The method of claim 1, wherein the duration is 2 to 15 seconds per nasal cavity.

13. The method of claim 1, wherein the flow rate is from 2 cc/sec to 5 cc/sec.

14. The method of claim 1, wherein the flow rate is from 4 cc/sec to 5 cc/sec.

15. The method of claim 1 wherein the gas comprises at least 50% carbon dioxide.

16. The method of claim 1 wherein the gas comprises at least 70% carbon dioxide.

17. The method of claim 1 wherein the gas comprises substantially pure carbon dioxide.