Methods of stimulating fat mobilization using a polymer conjugated polyphenol
First Claim
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1. A method of stimulating fat mobilization, the method comprising the steps of:
- providing a polyphenol;
conjugating the polyphenol to a polymer selected from the group consisting of polyethylene glycol, polyglycolide, polylactide, polyvinyl alcohol, polyacrylic acid, hyaluronic acid and polyamidoamine;
administering to a subject suffering from dyslipidemia, the polyphenol conjugated to the polymer; and
binding the polyphenol conjugated to the polymer to a protein comprising an amino acid sequence Arg-Gly-Asp (RGD) recognition site, leading to increased phosphorylation of AMP kinase (AMPK), stimulating fat mobilization.
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Abstract
Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
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Citations
5 Claims
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1. A method of stimulating fat mobilization, the method comprising the steps of:
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providing a polyphenol; conjugating the polyphenol to a polymer selected from the group consisting of polyethylene glycol, polyglycolide, polylactide, polyvinyl alcohol, polyacrylic acid, hyaluronic acid and polyamidoamine; administering to a subject suffering from dyslipidemia, the polyphenol conjugated to the polymer; and binding the polyphenol conjugated to the polymer to a protein comprising an amino acid sequence Arg-Gly-Asp (RGD) recognition site, leading to increased phosphorylation of AMP kinase (AMPK), stimulating fat mobilization. - View Dependent Claims (2, 3, 4, 5)
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Specification