Dual drug pen-injection device with micro-reservoirs carrying secondary drug for emergency injection

• US 9,272,093 B2
• Filed: 02/08/2012
• Issued: 03/01/2016
• Est. Priority Date: 02/09/2011
• Status: Active Grant

• Current Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Original Assignee: Sanofi-Aventis Deutschland GmbH (Sanofi )
• Inventors: Kohli, Amit, Lerche, Christian
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Lee, Morgan
• Application Number:
  US13/981,543
• Publication Number:
  US 20130324920A1
• Time in Patent Office: 1,483 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/26 Glucagons
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2205/0244 Micromachined materials, e.g. made from silicon wafers, microelectromechanical systems [MEMS] or comprising nanotechnology
• CPC Class Codes: A61M 2205/13 with means for the detection of operative contact with patient, e.g. lip sensor
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 5/003 Kits for diabetics
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/2448 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/31 Details
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

An injection device to deliver at least two medicaments is disclosed where a first medicament is delivered in settable doses with a first medicament dose delivery mechanism and a second medicament is delivered from micro-reservoirs upon activation of a second medicament delivery system, whereby activation of the second medicament delivery system locks out the first medicament dose delivery mechanism.

Claims

1. A drug delivery device, comprising,

a cartridge of a first medicament;

a first medicament dose delivery mechanism configured for user settable administration of multiple doses of the first medicament through a dispense interface;

a plurality of micro-reservoirs of a second medicament; and

a second medicament delivery system configured to deliver a preset dose of the second medicament through a second dispense interface, the second medicament delivery system comprising a lock out feature,

wherein activation of the lock out feature of the second medicament delivery system locks out to physically disable the first dose delivery mechanism preventing

both dose setting and dose administration of the first medicament.

2. The drug delivery device of claim 1 where the second medicament delivery system comprises a microchip coupled to a microprocessor for controlling delivery of the preset dose.

3. The drug delivery device of claim 1 where the dispense interface is a needle cannula.

4. The drug delivery device of claim 1 further comprising an electronic circuit system coupled to the second medicament delivery system configured to output a plurality of electronic outputs instructing a user of the drug delivery device on how to administer a dose of the second medicament.

5. The drug delivery device of claim 1 further comprising an electronic circuit system coupled to the second medicament delivery system configured to transmit to a receiver, a signal indicating activation of the second medicament delivery system.

6. The drug delivery device of claim 1 where the drug delivery device is configured as a pen-type injection device.

7. The drug delivery device of claim 1 where the second medicament delivery system comprises an electromechanical microchip configured to formulate the second medicament through a reconstitution step and subsequently deliver a non-user settable dose of the second medicament through a needle cannula.

8. The drug delivery device of claim 1 where the second medicament delivery system is programmable through a wireless connection.

9. The drug delivery device of claim 1 where the first medicament is insulin and the second medicament is glucagon solution.

10. The drug delivery device of claim 9 where the glucagon solution is formulated by the second medicament delivery system through reconstitution of lyophilized glucagon and a liquid excipient.

11. A drug delivery device, comprising,

a cartridge of a first medicament;

a first medicament dose delivery mechanism configured for user settable administration of multiple doses of the first medicament through a dispense interface;

a plurality of micro-reservoirs of a second medicament; and

a second medicament delivery system configured to deliver a preset dose of the second medicament through a second dispense interface, the second medicament delivery system comprising a lock out feature,

wherein activation of the lock out feature of the second medicament delivery system locks out to physically disable the first dose delivery mechanism preventing

both dose setting and dose administration of the first medicament

wherein the lock out feature comprises an electromechanical triggering mechanism.

12. The drug delivery device of claim 11 where the second medicament delivery system comprises a microchip coupled to a microprocessor for controlling delivery of the preset dose.

13. The drug delivery device of claim 11 where the dispense interface is a needle cannula.

14. The drug delivery device of claim 11 further comprising an electronic circuit system coupled to the second medicament delivery system configured to output a plurality of electronic outputs instructing a user of the drug delivery device on how to administer a dose of the second medicament.

15. The drug delivery device of claim 11 further comprising an electronic circuit system coupled to the second medicament delivery system configured to transmit to a receiver, a signal indicating activation of the second medicament delivery system.

16. The drug delivery device of claim 11 where the drug delivery device is configured as a pen-type injection device.

17. The drug delivery device of claim 11 where the second medicament delivery system comprises an electromechanical microchip configured to formulate the second medicament through a reconstitution step and subsequently deliver a non-user settable dose of the second medicament through a needle cannula.

18. The drug delivery device of claim 11 where the second medicament delivery system is programmable through a wireless connection.

19. The drug delivery device of claim 11 where the first medicament is insulin and the second medicament is glucagon solution.

20. The drug delivery device of claim 19 where the glucagon solution is formulated by the second medicament delivery system through reconstitution of lyophilized glucagon and a liquid excipient.