Systems and devices for selective cell lysis and methods of using same
First Claim
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1. A system for the generation and delivery of microbubbles, comprising:
- a liquid reservoir configured to contain a fluid;
a gas reservoir configured to contain a gas or vapor;
a bubble generator,wherein the bubble generator is in fluidic communication with the liquid reservoir and the gas reservoir,wherein the bubble generator is configured to receive liquid from the liquid reservoir and gas from the gas reservoir and combine the received liquid and gas to create a solution comprising microbubbles;
a fluid injection device,wherein the fluid injection device comprises a needle array comprising one or more needles; and
wherein the fluid injection device is in fluidic communication with the bubble generator and is configured to receive the solution comprising microbubbles and to inject the solution comprising microbubbles into a region of target tissue.
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Abstract
A device for generating microbubbles in a gas and liquid mixture and injection device, the device comprising: a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; a needle array removably attached to the housing and in fluid connection with the mixing chamber, the needle array including at least one needle; and at least one pressure sensor for measuring tissue apposition pressure, the pressure sensor being mounted on one of the housing and the needle array.
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20 Claims
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1. A system for the generation and delivery of microbubbles, comprising:
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a liquid reservoir configured to contain a fluid; a gas reservoir configured to contain a gas or vapor; a bubble generator, wherein the bubble generator is in fluidic communication with the liquid reservoir and the gas reservoir, wherein the bubble generator is configured to receive liquid from the liquid reservoir and gas from the gas reservoir and combine the received liquid and gas to create a solution comprising microbubbles; a fluid injection device, wherein the fluid injection device comprises a needle array comprising one or more needles; and wherein the fluid injection device is in fluidic communication with the bubble generator and is configured to receive the solution comprising microbubbles and to inject the solution comprising microbubbles into a region of target tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A system for the generation and delivery of microbubbles, comprising:
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a gas source; a solution container comprising a solution; a solution agitator in fluidic communication with the solution container and the gas source, wherein the solution agitator is configured to receive gas from the gas source and solution from the solution container and mix the gas and the solution to form a solution comprising microbubbles; and an injection member comprising at least one needle, wherein the injection member is in fluidic communication with the solution agitator and is configured to receive the solution comprising microbubbles and to inject the solution comprising microbubbles into a region of target tissue. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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20. A system for the generation and delivery of microbubbles, comprising:
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a liquid reservoir configured to contain a fluid; a bubble generator; a filter element configured to filter a gas or vapor prior to the gas or vapor being passed to the bubble generator, wherein the bubble generator is in fluidic communication with the liquid reservoir and the filter element, wherein the bubble generator is configured to receive liquid from the liquid reservoir and gas or vapor filtered through the filter element and combine the received liquid and gas or vapor to create a solution comprising microbubbles; a fluid injection device, wherein the fluid injection device comprises a needle array comprising one or more needles; and wherein the fluid injection device is in fluidic communication with the bubble generator and is configured to receive the solution comprising microbubbles and to inject the solution comprising microbubbles into a region of target tissue.
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Specification