Implantable medical device with active detection of atrial mechanical activity

• US 9,272,146 B2
• Filed: 11/27/2013
• Issued: 03/01/2016
• Est. Priority Date: 11/29/2012
• Status: Active Grant

• Current Assignee: Sorin CRM SAS (MicroPort Scientific Corp.)
• Original Assignee: Sorin CRM SAS (MicroPort Scientific Corp.)
• Inventors: Anselmi, Francesca
• Primary Examiner(s): Patton, Amanda
• Assistant Examiner(s): EDWARDS, PHILIP CHARLES
• Application Number:
  US14/092,574
• Publication Number:
  US 20140148713A1
• Time in Patent Office: 825 Days
• Field of Search: 600508-528, 607 1- 28
• US Class Current: 1/1
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/1102 Ballistocardiography
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61N 1/3624 occurring in the atrium, i.e. atrial tachycardia
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control

Abstract

A device includes a lead configured to for use in applying an atrioventricular delay (“AVD”), an acceleration sensor adapted to output an endocardial acceleration signal, and circuitry configured to receive and process said endocardial acceleration signal to provide ventricular pacing by varying, in a controlled manner, the AVD in a range having a plurality of AVD values. The circuitry derives from said endocardial acceleration signal a value of a parameter representative of an component of the endocardial acceleration signal corresponding to the first endocardial acceleration peak associated with an isovolumetric ventricular contraction (“EAX component”), and evaluates a degree of variation of said parameter values as a function of said plurality of AVD values to detect atrial and ventricular events.

Claims

1. A device, comprising:

a lead having at least one electrode;

an acceleration sensor adapted to output an endocardial acceleration signal;

circuitry configured to receive and process said endocardial acceleration signal and to provide ventricular pacing using the lead by varying, in a controlled manner, an atrioventricular delay (“

AVD”

) in a range having a plurality of AVD values,

wherein the circuitry derives from said endocardial acceleration signal a value of a parameter representative of a component of the endocardial acceleration signal corresponding to the first endocardial acceleration peak associated with an isovolumetric ventricular contraction (“

EAX component”

), and evaluates a degree of variation of said parameter values as a function of said plurality of AVD values to detect atrial and ventricular event;

wherein the circuitry is configured to evaluate said degree of variation of said parameter values as a function of said plurality of AVD values by calculating a difference between the values of the parameter collected for a first range of AVD values and the values of the parameter collected for a second range of AVD values, and wherein said first range of AVD values includes a plurality of short AVD values and said second range of AVD values, distinct from said first range of AVD values, includes a plurality of long AVD values; and

wherein the circuitry is further configured to discriminate between a normal atrial mechanical activity, when said difference exceeds a predetermined threshold, and an absent or deficient atrial mechanical activity when said difference does not exceed said predetermined threshold.

2. The device of claim 1, wherein the AVD is counted from the detection of a spontaneous or stimulated atrial event and after which a ventricular stimulation is delivered in the absence of detection of a corresponding spontaneous ventricular event.

3. The device of claim 1, wherein the circuitry is configured to discriminate, as a function of said degree of variation of parameter values, between normal atrial mechanical activity and an absent or deficient atrial activity, despite an observable electrical activity in sinus rhythm.

4. The device of claim 1, wherein said parameter is the amplitude between extremes of the EAX component of the endocardial acceleration signal.

5. The device of claim 1, wherein said parameter is the energy of the EAX component of the endocardial acceleration signal.

6. The device of claim 1, wherein the circuitry is configured to evaluate said degree of variation of said parameter values as a function of said plurality of AVD values by calculating a standard deviation of the parameter values collected for said plurality of AVD values.

7. The device of claim 1, wherein the circuitry is configured to evaluate said degree of variation of said parameter values as a function of said plurality of AVD values by modeling a sigmoid characteristic of the parameter values as a function of said plurality of AVD values, with two plateaus, one on each side of a central transition portion.

8. The device of claim 1, further comprising memory configured to store an index of said degree of variation of the parameter values, wherein said memory is further configured to provide a history of the evolution of said index over time.

9. The device of claim 8, wherein the circuitry is configured to, upon the occurrence of an episode of atrial fibrillation (AF), compare the stored values of said index prior to the episode of atrial fibrillation (AF) and post the episode of atrial fibrillation (AF), and is configured to derive from this comparison a recovery indicator, or an indicator of an absence of recovery after atrial fibrillation (AF).

10. A device, comprising:

a lead having at least one electrode;

an acceleration sensor adapted to output an endocardial acceleration signal;

circuitry configured to receive and process said endocardial acceleration signal and to provide ventricular pacing using the lead by varying, in a controlled manner, an atrioventricular delay (“

AVD”

) in a range having a plurality of AVD values,

wherein the circuitry derives from said endocardial acceleration signal a value of a parameter representative of a component of the endocardial acceleration signal corresponding to the first endocardial acceleration peak associated with an isovolumetric ventricular contraction (“

EAX component”

), and evaluates a degree of variation of said parameter values as a function of said plurality of AVD values to detect atrial and ventricular events;

wherein the circuitry is configured to evaluate said degree of variation of said parameter values as a function of said plurality of AVD values by calculating a standard deviation of the parameter values collected for said plurality of AVD values; and

wherein the circuitry is further configured to discriminate between a normal atrial mechanical activity, when said standard deviation exceeds a predetermined threshold, and an absent or deficient atrial mechanical activity when said standard deviation does not exceed said predetermined threshold.

11. A device, comprising:

a lead having at least one electrode;

an acceleration sensor adapted to output an endocardial acceleration signal;

circuitry configured to receive and process said endocardial acceleration signal and to provide ventricular pacing using the lead by varying, in a controlled manner, an atrioventricular delay (“

AVD”

) in a range having a plurality of AVD values,

wherein the circuitry derives from said endocardial acceleration signal a value of a parameter representative of a component of the endocardial acceleration signal corresponding to the first endocardial acceleration peak associated with an isovolumetric ventricular contraction (“

EAX component”

), and evaluates a degree of variation of said parameter values as a function of said plurality of AVD values to detect atrial and ventricular events;

wherein the circuitry is configured to evaluate said degree of variation of said parameter values as a function of said plurality of AVD values by modeling a sigmoid characteristic of the parameter values as a function of said plurality of AVD values, with two plateaus, one on each side of a central transition portion; and

wherein the circuitry is further configured to discriminate between a normal atrial mechanical activity, when the absolute level difference of the two plateaus is larger than a predetermined threshold, and an absent or deficient atrial mechanical activity when the absolute level difference of the two plateaus is not larger than said predetermined threshold.

12. A device, comprising:

a lead having at least one electrode;

an acceleration sensor adapted to output an endocardial acceleration signal;

circuitry configured to receive and process said endocardial acceleration signal and to provide ventricular pacing using the lead by varying, in a controlled manner, an atrioventricular delay (“

AVD”

) in a range having a plurality of AVD values,

wherein the circuitry derives from said endocardial acceleration signal a value of a parameter representative of a component of the endocardial acceleration signal corresponding to the first endocardial acceleration peak associated with an isovolumetric ventricular contraction (“

EAX component”

), and evaluates a degree of variation of said parameter values as a function of said plurality of AVD values to detect atrial and ventricular events;

memory configured to store an index of said degree of variation of the parameter values, wherein said memory is further configured to provide a history of the evolution of said index over time;

a stimulation device configured to provide atrial stimulation; and

wherein the circuitry is configured to provide an atrial paced event, and wherein the circuitry is configured to detect atrial activity in the presence of at least a spontaneous atrial event and at least an atrial paced event, and wherein the circuitry is configured to compare stored values of said index corresponding to the spontaneous atrial event with stored values of said index corresponding to the paced atrial event and to derive from this comparison a warning indicator in case of discrepancy between the respective compared indexes.