Medical devices with an activated coating

• US 9,273,191 B2
• Filed: 02/22/2010
• Issued: 03/01/2016
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc), Sofradim Production
• Original Assignee: Covidien LP (Medtronic Plc), Sofradim Production
• Inventors: Ladet, Sbastien, Hadba, Ahmad Robert
• Primary Examiner(s): ZISKA, SUZANNE E
• Application Number:
  US13/202,390
• Publication Number:
  US 20120021037A1
• Time in Patent Office: 2,199 Days
• US Class Current: 1/1
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2420/02 Methods for coating medical devices
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: B05D 1/00 Processes for applying liquids or other fluent materials B05D5/00, B05D7/00 take precedence
• CPC Class Codes: C08J 7/0427 with only one layer of a composition containing a polymer binder with more layers C08J7/042
• CPC Class Codes: C08L 101/02 characterised by the presence of specified groups , e.g. terminal or pendant functional groups
• CPC Class Codes: D06M 15/01 with natural macromolecular compounds or derivatives thereof with natural rubber or derivatives thereof D06M15/693

Abstract

Implantable medical devices include a substrate having applied thereto a coating including a polymeric material possessing a core and at least one functional group known to have click reactivity.

Claims

1. A medical device comprising a polymeric textile having a coating, the coating comprising a natural polymer possessing a functional group having click reactivity selected from the group consisting of thiols, azides, alkynes and alkenes, wherein the coating imparts an activated surface to the textile via the functional group having click reactivity, wherein the natural polymer is selected from the group consisting of chitosan, collagen, hyaluronic acid, polysaccharides and copolymers and combinations thereof.

2. The medical device according to claim 1, wherein the functional group known to have click reactivity is a thiol.

3. The medical device according to claim 1, wherein the functional group known to have click reactivity is an azide.

4. The medical device according to claim 1, wherein the functional group known to have click reactivity is an alkyne.

5. The medical device according to claim 1, wherein the functional group known to have click reactivity is an alkene.

6. The medical device according to claim 1, wherein the natural polymer is chitosan.

7. The medical device of claim 1, wherein the polymeric textile is a surgical mesh.

8. The medical device of claim 1, wherein the polymeric textile is a sling.

9. The medical device of claim 1, further comprising a bioactive agent possessing a functional group having click reactivity complementary to the functional group having click reactivity of the coating, wherein the bioactive agent is covalently bonded to the surface of the coated polymeric textile via the activated surface.

10. The medical device of claim 9, wherein the bioactive agent is selected from the group consisting of anti-adhesives, antimicrobials, analgesics, antipyretics, anesthetics, antiepilutics, antihistamines, anti-intlammatories, cardiovascular drugs, diagnostic agents, synipathominietics, cholinomimetics, anti ics, antispasmodics, muscle relaxants adrenergic neuron Mockers, antineoplastics, immunogenic agents, immunosuppressants, gastrointestinal drugs, diuretics, steroids, lipids, platelet activating drugs, clotting factors chemotherapeutics and combinations thereof.