Method for improving measurement accuracy and devices and systems related thereto
First Claim
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1. A method for measuring hematocrit of a sample, the method comprising:
- contacting the sample with a sensor inserted into a meter, the sensor comprising a sample chamber comprising a first electrode, a second electrode, and a third electrode, the meter comprising a memory and a processor for executing instructions stored in a memory of the instrument, the instructions comprising instructions for;
determining fill-time by measuring time elapsed between detecting a signal between the first electrode and the second electrode and another signal between the first electrode and the third electrode, wherein the fill-time is related to hematocrit of the sample;
measuring a first signal at the second electrode after the sample chamber is substantially filled with the sample, wherein the first signal is substantially independent of the analyte concentration and is related to hematocrit of the sample;
measuring a second signal at the third electrode, wherein the second signal is related to hematocrit of the sample;
deriving, by using the processor executing instructions stored in the memory, a first hematocrit value, a second hematocrit value and a third hematocrit value of the property using the fill-time, the first signal, and the second signal, respectively;
comparing the first, second, and third hematocrit values to determine whether one of the values is an outlier; and
calculating a single hematocrit value of the property based on at least two of the first, second, and third hematocrit values that are in agreement.
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Abstract
The present disclosure relates to methods and devices for providing accurate measurement of a property of a sample. The method comprises obtaining a plurality of independent measurements of the property. The plurality of values of the property of the sample obtained by the plurality of independent measurements is compared to determine whether one or more of the values is an outlier.
31 Citations
31 Claims
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1. A method for measuring hematocrit of a sample, the method comprising:
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contacting the sample with a sensor inserted into a meter, the sensor comprising a sample chamber comprising a first electrode, a second electrode, and a third electrode, the meter comprising a memory and a processor for executing instructions stored in a memory of the instrument, the instructions comprising instructions for; determining fill-time by measuring time elapsed between detecting a signal between the first electrode and the second electrode and another signal between the first electrode and the third electrode, wherein the fill-time is related to hematocrit of the sample; measuring a first signal at the second electrode after the sample chamber is substantially filled with the sample, wherein the first signal is substantially independent of the analyte concentration and is related to hematocrit of the sample; measuring a second signal at the third electrode, wherein the second signal is related to hematocrit of the sample; deriving, by using the processor executing instructions stored in the memory, a first hematocrit value, a second hematocrit value and a third hematocrit value of the property using the fill-time, the first signal, and the second signal, respectively; comparing the first, second, and third hematocrit values to determine whether one of the values is an outlier; and calculating a single hematocrit value of the property based on at least two of the first, second, and third hematocrit values that are in agreement. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for using an analyte sensor, the method comprising:
- contacting a sample comprising an analyte with an analyte sensor comprising a sample chamber comprising a first electrode, a second electrode, and a third electrode;
an enzyme responsive to the analyte and a redox mediator;using an analyte measurement instrument in which the analyte sensor is inserted to determine concentration of the analyte, the analyte measurement instrument comprising a processor for executing instructions stored in a memory of the instrument, the instructions comprising instructions for; determining fill-time by measuring time elapsed between detecting a signal between the first electrode and the second electrode and another signal between the first electrode and the third electrode, wherein the fill-time is related to hematocrit of the sample; measuring a first signal at the second electrode after the sample chamber is substantially filled with the sample, wherein the first signal is substantially independent of the analyte concentration and is related to hematocrit of the sample; measuring an analyte related signal at the second electrode after measuring the first signal; measuring a second signal at the third electrode after measuring the analyte related signal, wherein the second signal is related to hematocrit of the sample; deriving first, second, and third hematocrit values of the sample using the fill-time, the first signal, and the second signal; comparing the first, second, and third hematocrit values of the sample; calculating a single hematocrit value based on at least two of the first, second and third hematocrit values when the at least two of the first, second, and third hematocrit values are in agreement; determining concentration of the analyte; and correcting the concentration of the analyte according to the single hematocrit value. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
- contacting a sample comprising an analyte with an analyte sensor comprising a sample chamber comprising a first electrode, a second electrode, and a third electrode;
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26. A method for determining analyte concentration of a sample using an analyte sensor and a meter, the method comprising:
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contacting the sample with the analyte sensor inserted into the meter, the analyte sensor comprising a sample chamber comprising a reference/counter electrode, a working electrode, a trigger electrode, an enzyme responsive to the analyte, and a redox mediator; using the meter comprising a processor for executing instructions stored in a memory of the meter, the instructions comprising instructions for; determining fill-time by measuring time elapsed between detecting a signal between the reference/counter electrode and the working electrode and another signal between the reference/counter electrode and the trigger electrode, wherein the fill-time is related to hematocrit of the sample; disconnecting the reference/counter electrode from the working electrode and from the trigger electrode after the sample chamber is substantially filled with the sample; reconnecting the reference/counter electrode to the working electrode and the trigger electrode; measuring a first signal at the working electrode, wherein the first signal is substantially independent of the analyte concentration and is related to hematocrit of the sample; measuring an analyte related signal at the working electrode after measuring the first signal; measuring a second signal at the trigger electrode after measuring the analyte related signal, wherein the second signal is related to hematocrit of the sample; deriving first, second, and third hematocrit values of the sample using the fill-time, the first signal, and the second signal; comparing the first, second, and third hematocrit values of the sample; calculating a single hematocrit value based on at least two of the first, second and third hematocrit values when the at least two of the first, second, and third hematocrit values are in agreement; determining concentration of the analyte; and correcting the concentration of the analyte according to the single hematocrit value. - View Dependent Claims (27, 28, 29, 30, 31)
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Specification