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Methods for assessing cell culture fluid by impedance spectra

  • US 9,274,071 B2
  • Filed: 12/30/2013
  • Issued: 03/01/2016
  • Est. Priority Date: 12/30/2013
  • Status: Active Grant
First Claim
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1. A method for assessing a cell culture reaction fluid of a cell culture reaction, comprising the steps of:

  • generating a plurality of frequencies with a sensor comprising a sensing region in operational contact with the cell culture reaction fluid and a plurality of tuning circuits outside the fluid;

    receiving a signal from the sensor, wherein the signal is representative of impedance spectra of the sensing region in operational contact with the cell culture reaction fluid over a measured spectral frequency range;

    analyzing the impedance spectra; and

    determining one or more properties of the cell culture reaction fluid based on the analyzed impedance spectra.

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