Methods and devices for evaluating and treating a bone condition on x-ray image analysis

• US 9,275,469 B2
• Filed: 12/04/2014
• Issued: 03/01/2016
• Est. Priority Date: 10/11/2000
• Status: Expired due to Term

• Current Assignee: Imatx, Inc. (Conformis Incorporated)
• Original Assignee: Imatx, Inc. (Conformis Incorporated)
• Inventors: Lang, Philipp, Steines, Daniel, Liew, Siau-Way, Vargas-Voracek, Rene, Arnaud, Claude D.
• Primary Examiner(s): ANSARI, TAHMINA N
• Application Number:
  US14/560,642
• Publication Number:
  US 20150193944A1
• Time in Patent Office: 453 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 6/4423 related to hygiene or sterilisation
• CPC Class Codes: A61B 6/482 involving multiple energy imaging
• CPC Class Codes: A61B 6/505 for diagnosis of bone
• CPC Class Codes: A61B 6/583 using calibration phantoms
• CPC Class Codes: G06T 2207/10116 X-ray image
• CPC Class Codes: G06T 2207/30008 Bone
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G06T 7/20 Analysis of motion motion estimation for coding, decoding, compressing or decompressing digital video signals H04N19/43, H04N19/51

Abstract

This disclosure relates to methods and devices for analyzing x-ray images. Futhermore, bone condition of a subject can be evaluated by analyzing x-ray images of the subject'"'"'s bone and therapies can then be selected or devised for the subject.

Claims

1. A method of deriving quantitative information about a bone structure parameter in a subject comprising:

(a) analyzing, using a computer system, an image of a bone of the subject; and

(b) deriving quantitative information on one or more bone structure parameters from a sliding regions of interest (ROI) on the image.

2. The method of claim 1, wherein the ROI is adapted to the image and derived from a model set of ROIs having similar anatomical landmarks.

3. The method of claim 1, wherein the bone structure includes trabecular bone structure.

4. The method of claim 1, wherein the quantitative information on bone structure includes one or more bone microarchitecture parameters.

5. The method of claim 1, wherein the quantitative information on bone structure includes one or more bone macroanatomical parameters.

6. The method of claim 1, wherein the quantitative information on bone structure includes a single index of combined bone structure parameters.

7. The method of claim 1, further comprising comparing the quantitative information with information in a database of bone structure measurements obtained from selected subjects.

8. The method of claim 1, wherein the determining comprises diagnosing bone disease.

9. The method of claim 8, further comprising:

assessing one or more macro-anatomical parameters in said image,

assessing bone mineral density and bone structure parameters in said image, and

combining the assessments to diagnose the bone disease.

10. The method of claim 1, wherein the determining comprises monitoring progression of bone disease.

11. The method of claim 1, further comprising selecting a therapy based on the bone condition and administering said therapy to said subject.

12. The method of claim 11, wherein the determining comprises monitoring progression of bone disease during or after administration of said selected therapy.

13. The method of claim 1, wherein the ROI is moved on a pixel-by-pixel basis on the image.

14. The method of claim 1, wherein the ROI is placed on the image using a regularized active shape algorithm.

15. The method of claim 1, wherein the ROI is located automatically.