Estimating apparatus and estimating method

• US 9,277,865 B2
• Filed: 03/07/2011
• Issued: 03/08/2016
• Est. Priority Date: 03/15/2010
• Status: Expired due to Fees

• Current Assignee: Arai Medphoton Research Laboratories Corporation
• Original Assignee: Arai Medphoton Research Laboratories Corporation
• Inventors: Yamaguchi, Takashi, Hakomori, Shiho, Tamamura, Koshi, Arai, Tsunenori, Ito, Arisa, Uchiyama, Jun
• Primary Examiner(s): Nguyen, Anhtuan T
• Assistant Examiner(s): WOO, JAE KYUN
• Application Number:
  US13/583,531
• Publication Number:
  US 20130123642A1
• Time in Patent Office: 1,828 Days
• Field of Search: 600/312, 604/890.1
• US Class Current: 1/1
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 2018/00351 Heart
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/318 Heart-related electrical modalities, e.g. electrocardiography [ECG]
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61B 5/6869 Heart
• CPC Class Codes: A61N 2005/0602 for treatment of blood vessels
• CPC Class Codes: A61N 2005/0626 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

A photodynamic therapy apparatus as an estimating apparatus is an apparatus for irradiating a tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, including a connector, a light source, and a light detection unit. The laser catheter is capable of being attached to and detached from the connector. The light source outputs the excitation light to the laser catheter via the connector. The light detection unit detects intensity or a spectrum of the fluorescence, the fluorescence being entered from the laser catheter via the connector, to estimate whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser catheter and the photo-sensitive pharmaceutical absorbed in the tissue.

Claims

1. An estimating apparatus for therapy for atrial fibrillation, for irradiating a cardiac-muscle tissue having absorbed photo-sensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter, comprising:

a connector which the laser catheter is capable of being attached to and detached from;

a light source for outputting the excitation light to the laser catheter via the connector;

a detection unit for detecting fluorescence, the fluorescence entering the detection unit from the laser catheter via the connector, to estimate whether the cardiac-muscle tissue is changed because of reaction between the excitation light emitted from the tip portion of the laser catheter and the photo-sensitive pharmaceutical absorbed in the cardiac-muscle tissue, and

whether a contact state of the tip portion of the laser catheter with respect to the cardiac-muscle tissue has changed; and

a controller for simultaneously estimating whether the cardiac-muscle tissue has changed because of the reaction between the excitation light emitted from the tip portion of the laser catheter and the photosensitive pharmaceutical absorbed in the cardiac-muscle tissue, and the contact state of the tip portion of the laser catheter with respect to the cardiac-muscle tissue, the controller calculating fluorescence intensity and determining the non-contact state if the controller determines that the fluorescence intensity is equal to or larger than a first threshold;

determining the upright-contact state if the controller determines that the minimum value of the fluorescence intensity is equal to or smaller than a second threshold, which is smaller than the first threshold;

determining the slanting-contact state if the controller determines that the fluorescence intensity periodically fluctuates between the first threshold and the second threshold;

determining whether the fluorescence intensity is attenuated below a threshold; and

estimating that there is a cytocidal effect on a tissue irradiated with the excitation light if the controller determines that the fluorescence intensity is attenuated below the threshold.

2. The estimating apparatus according to claim 1, wherein the controller visually reflects a current-estimated-result of the change of the tissue in a peak-estimated-result of the change of the tissue, and outputs a signal for simultaneously informing of the estimated result of the change of the tissue and the estimated result of the contact state.

3. The estimating apparatus according to claim 2, further comprising storage for storing the peak-estimated-result of the change of the tissue, wherein the controller records the current-estimated-result of the change of the tissue in the storage, updates, in a case where the current-estimated-result of the change of the tissue is equal to or larger than the peak-estimated-result of the change of the tissue recorded in the storage, the peak-estimated-result of the change of the tissue recorded in the storage with the current-estimated-result of the change of the tissue, and outputs a signal for simultaneously informing of the estimated result of the change of the tissue and the estimated result of the contact state, by displaying the current-estimated-result of the change of the tissue on the updated peak-estimated-result of the change of the tissue in an overlapped manner.

4. The estimating apparatus according to claim 1, wherein the controller outputs a signal for informing whether the tissue has changed, based on the estimated result.

5. The estimating apparatus according to claim 1, wherein the controller outputs a signal to prompt to change an irradiation condition of the excitation light, based on the estimated result.

6. The estimating apparatus according to claim 1, wherein the controller obtains an electrocardiographic signal, and estimates whether the tissue has changed, based on a correlation between the electrocardiographic signal and the intensity of the fluorescence.

7. The estimating apparatus according to claim 1, wherein the controller visually represents a peak-estimated-result of the change of the cardiac-muscle tissue in a current-estimated-result of the change of the cardiac-muscle tissue, and outputs a signal for simultaneously informing of the estimated result of the change of the cardiac-muscle tissue and the estimated result of the contact state.

8. The estimating apparatus according to claim 7, further comprising storage for storing the peak-estimated-result of the change of the cardiac-muscle tissue, wherein the controller records the current-estimated-result of the change of the cardiac-muscle tissue in the storage, updates, in a case where the current-estimated-result of the change of the cardiac-muscle tissue is equal to or larger than the peak-estimated-result of the change of the cardiac-muscle tissue recorded in the storage, the peak-estimated-result of the change of the cardiac-muscle tissue recorded in the storage with the current-estimated-result of the change of the cardiac-muscle tissue, and outputs a signal for simultaneously informing of the estimated result of the change of the cardiac-muscle tissue and the estimated result of the contact state, by displaying the current-estimated-result of the change of the cardiac-muscle tissue on the updated peak-estimated-result of the change of the cardiac-muscle tissue in an overlapped manner.

9. An estimating method, comprising:

irradiating a tissue having absorbed photosensitive pharmaceutical, the photo-sensitive pharmaceutical absorbing an excitation light and emitting fluorescence, with the excitation light emitted from a tip portion of a laser catheter;

extracting the fluorescence corresponding to the irradiated excitation light via the laser catheter; and

simultaneously estimating whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser catheter and the photo-sensitive pharmaceutical absorbed in the tissue, and the contact state of the tip portion of the laser catheter with respect to the tissue, based on intensity of the extracted fluorescence,

calculating fluorescence intensity and determining the non-contact state if a controller determines that the fluorescence intensity is equal to or lamer than a first threshold;

determining the upright-contact state if the controller determines that the minimum value of the fluorescence intensity is equal to or smaller than a second threshold, which is smaller than the first threshold;

the controller determines the slanting-contact state if the controller determines that the fluorescence intensity periodically fluctuates between the first threshold and the second threshold;

determining whether the fluorescence intensity is attenuated below a threshold; and

estimating that there is a cytocidal effect on a tissue irradiated with the excitation light if the controller determines that the fluorescence intensity is attenuated below the threshold.

10. The estimating method according to claim 9, further comprising:

visually reflecting a current-estimated-result of the change of the tissue in a peak-estimated-result of the change of the tissue, and outputting a signal for simultaneously informing of the estimated result of the change of the tissue and the estimated result of the contact state.

11. The estimating method according to claim 10, further comprising:

recording the current-estimated-result of the change of the tissue in storage, updating, in a case where the current-estimated-result of the change of the tissue is equal to or larger than the peak-estimated-result of the change of the tissue recorded in the storage, the peak-estimated-result of the change of the tissue recorded in the storage with the current-estimated-result of the change of the tissue, and outputting a signal for simultaneously informing of the estimated result of the change of the tissue and the estimated result of the contact state, by displaying the current-estimated-result of the change of the tissue on the updated peak-estimated-result of the change of the tissue in an overlapped manner.

12. The estimating method according to claim 9, further comprising:

obtaining an electrocardiographic signal, and estimating whether the tissue has changed, based on a correlation between the electrocardiographic signal and the intensity of the fluorescence.

13. An estimating method using photo-sensitive pharmaceutical absorbing an excitation light and emitting a fluorescence, a laser catheter capable of emitting the excitation light from a tip portion, and an estimating apparatus including a connector to/from which the laser catheter is capable of being attached/detached and a light source for outputting the excitation light to the laser catheter via the connector, comprising:

absorbing, in a tissue, the photo-sensitive pharmaceutical;

leading the tip portion of the laser catheter to the tissue having absorbed the photo-sensitive pharmaceutical, the laser catheter being attached to the connector;

irradiating the tissue having absorbed the photosensitive pharmaceutical with the excitation light emitted from the tip portion of the laser catheter, the excitation light being output from the light source;

extracting the fluorescence corresponding to the irradiated excitation light via the laser catheter; and

simultaneously estimating whether the tissue has changed because of reaction between the excitation light emitted from the tip portion of the laser catheter and the photosensitive pharmaceutical absorbed in the tissue, and the contact state of the tip portion of the laser catheter with respect to the tissue, based on intensity of the extracted fluorescence,

calculating fluorescence intensity and determining the non-contact state if a controller determines that the fluorescence intensity is equal to or lamer than a first threshold;

determining the upright-contact state if the controller determines that the minimum value of the fluorescence intensity is equal to or smaller than a second threshold, which is smaller than the first threshold;

the controller determines the slanting-contact state if the controller determines that the fluorescence intensity periodically fluctuates between the first threshold and the second threshold;

determining whether the fluorescence intensity is attenuated below a threshold; and

estimating that there is a cytocidal effect on a tissue irradiated with the excitation light if the controller determines that the fluorescence intensity is attenuated below the threshold.

14. The estimating method according to claim 13, further comprising:

visually reflecting a current-estimated-result of the change of the tissue in a peak-estimated-result of the change of the tissue, and outputting a signal for simultaneously informing of the estimated result of the change of the tissue and the estimated result of the contact state.

15. The estimating method according to claim 14, further comprising:

recording the current-estimated-result of the change of the tissue in storage, updating, in a case where the current-estimated-result of the change of the tissue is equal to or larger than the peak-estimated-result of the change of the tissue recorded in the storage, the peak-estimated-result of the change of the tissue recorded in the storage with the current-estimated-result of the change of the tissue, and outputting a signal for simultaneously informing of the estimated result of the change of the tissue and the estimated result of the contact state, by displaying the current-estimated-result of the change of the tissue on the updated peak-estimated-result of the change of the tissue in an overlapped manner.

16. The estimating method according to claim 13, further comprising:

obtaining an electrocardiographic signal, and estimating whether the tissue has changed, based on a correlation between the electrocardiographic signal and the intensity of the fluorescence.