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Method and apparatus for analysis of turbid media via single-element detection using structured illumination

  • US 9,277,866 B2
  • Filed: 03/15/2013
  • Issued: 03/08/2016
  • Est. Priority Date: 11/19/2009
  • Status: Active Grant
First Claim
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1. An apparatus for determining surface or subsurface optical properties or structures of a sample of turbid media over an area of the sample comprising:

  • a source to expose an area of the sample to a structured illumination having a plurality of spatial features comprising one or more peaks and one or more valleys;

    one or more detection systems comprising an optical relay device and a detector coupled to the optical relay device, wherein the one or more detection systems are configured to collect an optical signal with no spatial dependence emitted from a first collection area at a first spatial location and a second collection area at a second spatial location on the surface of the sample within the area of the sample exposed to the structured illumination, wherein the second spatial location is spatially diverse from the first spatial location, the first and second collection areas at the first and second spatial locations being smaller in size than the area of the sample exposed to the structured illumination and having a dimension less than or equal to the length of an individual spatial feature of the plurality of spatial features of the structured illumination that illuminated the sample; and

    a signal processor coupled to the one or more detection systems and configured to reconstruct optical data from an individual optical signal with no spatial dependence collected from each of the first and second collection areas at the first and second spatial locations by the one or more detection systems and corresponding to the structured illumination.

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