Optical power modulation vital sign detection method and measurement device

• US 9,277,868 B2
• Filed: 06/17/2013
• Issued: 03/08/2016
• Est. Priority Date: 01/31/2007
• Status: Active Grant

• Current Assignee: Tarilian Laser Technologies, Limited (Huma Therapeutics Ltd.)
• Original Assignee: Tarilian Laser Technologies, Limited (Huma Therapeutics Ltd.)
• Inventors: Borgos, John A., Borgos, Thomas A., Pongratz, Troy
• Primary Examiner(s): Radkowski, Peter
• Application Number:
  US13/919,685
• Publication Number:
  US 20130324860A1
• Time in Patent Office: 995 Days
• Field of Search: 385/12
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0266 Optical strain gauges
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0082 adapted for particular medical purposes
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/02233 Occluders specially adapted therefor tourniquets A61B17/132
• CPC Class Codes: G01D 5/35345 using Amplitude variations to detect the measured quantity

Abstract

A vital sign measurement device includes a sensor fixation device, a sensor frame, an optical sensing system, and an output unit. The sensor fixation device is adapted to be placed against an anatomical location of a subject. The optical sensing system includes an optical waveguide, an optical source device to supply optical energy to the optical waveguide, and an optical detector to detect an amount of optical energy exiting the optical waveguide. The optical sensing system is adapted to sense an arterial pulse from the compression or flexing of at least a portion of the optical waveguide resulting in reduction of the amount of light exiting the optical waveguide. The output unit is configured to receive a signal indicative of the amount of light exiting the optical waveguide and to generate a measure of the vital sign based at least in part on the received signal.

Claims

1. A vital sign measurement device comprising:

a sensor pad adapted to be placed against an anatomical location of a subject, within which is an artery;

an optical sensing system comprising an optical waveguide comprising an elastomer, an optical source device to supply optical energy to a first end of the optical waveguide, and an optical detector to detect an amount of optical energy exiting the second end of optical waveguide;

a waveguide support structure comprising a non-compliant surface, the waveguide support structure supporting at least a portion of the optical waveguide, wherein the optical waveguide is positioned between the sensor pad and the waveguide support structure such that pressure applied to the sensor pad causes the optical waveguide to compress between the sensor pad and the wave guide support structure such that the optical sensing system will produce a reduction of the amount of optical energy exiting the second end of the optical waveguide; and

an output unit configured to receive a signal indicative of the amount of light exiting the second end of the optical waveguide and to generate a measure of the vital sign based at least in part on the received signal.

2. The vital sign measurement device of claim 1, further comprising a sensor fixation device comprising a cuff comprising an inflatable bladder adapted to apply pressure to the limb when inflated and thereby compress the artery within the limb.

3. The vital sign measurement device of claim 2, further comprising a pressure sensor to detect a pressure applied to the anatomical location, wherein the output unit receives a pressure input indicative of the pressure applied to the anatomical location from the pressure sensor, and wherein the output unit generates the vital sign using the signal indicative of the optical signal received and the pressure input.

4. The vital sign measurement device of claim 2, wherein the anatomical location of the subject is an upper arm, and the sensor frame is configured on the sensor fixation device so that the optical sensing system is positioned to sense movement due to a pulse of a brachial artery resulting in the compression or flexing of at least a portion of the compressible optical waveguide.

5. The vital sign measurement device of claim 1, wherein the optical waveguide comprises a core and a cladding.

6. The vital sign measurement device of claim 1, wherein the elastomer is selected from the group consisting of polysiloxane, polyurethane, polybutadine rubber, and combinations thereof.

7. The vital sign measurement device of claim 1, further comprising a flexible and incompressible support surface that supports the optical waveguide over substantially all of its length.

8. The vital sign measurement device of claim 1, wherein the optical source device and the optical detector are mounted on the surface of the waveguide support surface.

9. The vital sign measurement device of claim 1, wherein the optical sensing system is configured to detect optical signals representative of a series of arterial pulses and the output unit is adapted to determine a pulse waveform for each of the series of arterial pulses.

10. The vital sign measurement device of claim 1, wherein the optical detector is optically coupled to optical waveguide such that the optical detector receives substantially of the optical energy from the optical source that does not escape from the sides of the optical waveguide.

11. The vital sign measurement device of claim 1, wherein the vital sign is at least one of a heart rate, an arterial pulse waveform, a systolic blood pressure, a diastolic blood pressure, a mean arterial blood pressure, a pulse pressure, and an arterial compliance.

12. A method of measuring a vital sign in a subject, the method comprising:

transmitting optical energy into a first end of an optical waveguide comprising an elastomer, the optical waveguide positioned between a sensor pad and a waveguide support, the sensor pad being positioned against an anatomical location of a subject, within which is an artery, the optical waveguide being adapted to compress in response to an arterial pulse causing the sensor pad to move;

detecting, using an optical detector held by the sensor frame, an amount of optical energy exiting a second end of the optical waveguide and generating therefrom a signal indicative of optical energy received, the amount of optical energy exiting the second end of the optical waveguide changing in response to an arterial pulse; and

generating a measure of the vital sign using the generated signal indicative of the optical energy exiting the second end of the optical waveguide.

13. The method of claim 12, wherein the vital sign is at least one of a heart rate, an arterial pulse waveform, a systolic blood pressure, a diastolic blood pressure, a mean arterial blood pressure, a pulse pressure, and an arterial compliance.

14. The method of claim 12, further comprising a sensor frame held by a sensor fixation device, the method further comprising:

applying a pressure to the anatomical location of the subject with the sensor fixation device.

15. The method of claim 14, the method further comprising:

varying the pressure applied to the anatomical location with the sensor fixation device over a period of time; and

determining a series of pulse characteristics for arterial pulses during the period of time from changes in the amount of optical energy exiting the second end of the optical waveguide over the period of time, wherein the generated measure of the vital sign is based on the series of pulse characteristics during the period of time.

16. The method of claim 14, further comprising

obtaining a measured blood pressure measurement;

obtaining an initial pulse characteristic, at an initial time, and a subsequent pulse characteristic, at a subsequent time, using an input indicative of the amount of optical energy exiting the second end of the optical waveguide, wherein the measured blood pressure measurement was obtained at a measurement time closer to the initial time than to the subsequent time, wherein the generated measurement of the vital sign is based on the measured blood pressure measurement, the initial pulse characteristic, and the subsequent pulse characteristic.

17. The method of claim 16, wherein the initial pulse characteristic and the subsequent pulse characteristics comprise pulse amplitudes.

18. A method of measuring a subject'"'"'s blood pressure, the method comprising:

applying a varying pressure to an anatomical location of a subject, within which is an artery;

detecting an arterial pulse waveform with an optical power modulation sensor as a function of the applied and varied pressure, the optical power modulation sensor including an optical waveguide comprising an elastomer adapted to be compressed between a sensor pad and a waveguide support structure in response to an arterial pulse causing the sensor pad to move, the compression of the optical waveguide resulting in a reduction in the amount of light transmitted to an end of the optical waveguide, the arterial pulse waveform being detected from the amount of light exiting the end of the optical waveguide; and

determining a systolic blood pressure and a diastolic blood pressure based on the detected arterial pulse waveform as a function of the applied and varied pressure.