Short duration pulse grid pattern laser treatment and methods

• US 9,278,029 B2
• Filed: 10/19/2012
• Issued: 03/08/2016
• Est. Priority Date: 10/19/2011
• Status: Active Grant

• Current Assignee: Iridex Corporation
• Original Assignee: Iridex Corporation
• Inventors: Yee, Kingman, Buzuwa, Dave
• Primary Examiner(s): Crandall, Lynsey
• Assistant Examiner(s): Jenness, Nathan J
• Application Number:
  US13/656,332
• Publication Number:
  US 20130110206A1
• Time in Patent Office: 1,236 Days
• Field of Search: 606 4- 6
• US Class Current: 1/1
• CPC Class Codes: A61B 2018/00315 for treatment of particular body parts
• CPC Class Codes: A61B 2018/00589 Coagulation
• CPC Class Codes: A61F 2009/00863 Retina
• CPC Class Codes: A61F 2009/00897 Scanning mechanisms or algorithms
• CPC Class Codes: A61F 9/008 using laser
• CPC Class Codes: A61F 9/00821 for coagulation
• CPC Class Codes: A61F 9/00823 Laser features or special beam parameters therefor

Abstract

Embodiments of the invention provide systems and methods for treating the retina and/or other areas of a patient'"'"'s eye. The procedures may involve using one or more treatment beams (e.g., lasers) to cause photocoagulation or laser coagulation to finely cauterize ocular blood vessels and/or prevent blood vessel growth to induce one or more therapeutic benefits. In other embodiments, a series of short duration light pulses (e.g., between 5-15 microseconds) may be delivered to the retinal tissue with a thermal relaxation time delay between the pulse to limit the temperature rise of the target retinal tissue and thereby limit a thermal effect to only the retinal pigment epithelial layer. Such procedures may be used to treat diabetic retinopathy, macular edema, and/or other conditions of the eye. The treatment beam may be delivered within a treatment boundary or pattern defined on the retina of the patient'"'"'s eye.

Claims

1. A method for treating an eye of a patient comprising:

directing, via a scanning system of a laser treatment system, an aiming beam onto retinal tissue of the patient'"'"'s eye;

defining, via the aiming beam, a first target position, and a second target position;

directing, via the scanning system of the laser treatment system, a treatment beam onto the retinal tissue of the patient'"'"'s eye; and

delivering, via the treatment beam, a series of pulses onto the retinal tissue at the first and second target positions to treat the retinal tissue, wherein a duration of each pulse is sufficiently short so as to avoid inducing photocoagulation of the retinal tissue that results in visible tissue damage, wherein the series of pulses directed to each position induce photoactivation of a therapeutic healing at that position, wherein the treatment beam is scanned between the first target position and the second target position between each pulse of the series, wherein the treatment beam is scanned during a relaxation interval of a respective target position such that the retinal tissue at the respective target position relaxes, the relaxation interval comprising at least 190 microseconds, and wherein the treatment beam is returned to the previously treated first and second target positions within the eye to deliver an additional series of pulses after the respective relaxation interval.

2. The method of claim 1, wherein the treatment beam comprises an oval or oblong cross section, and wherein the method further comprises scanning the oval or oblong cross section treatment beam across the retinal tissue as each pulse is delivered to produce more circular incident light profiles on the retinal tissue as the treatment beam axis is scanned, the incident light profiles being more circular than incident light profiles produced with circular cross section treatment beams.

3. The method of claim 1, further comprising:

delivering the series of pulses onto the retinal tissue at a plurality of additional target positions to treat the retinal tissue;

wherein the treatment beam is scanned to a different one of the first target position, the second target position, and the plurality of additional target positions between each pulse of the series.

4. The method of claim 3, further comprising:

rescanning the treatment beam between the first target position, the second target position, and the plurality of additional target positions; and

delivering an additional series of pulses between the first target position, the second target position, and the plurality of additional target positions at approximately the same positions as the previous series of pulses were delivered.

5. The method of claim 3, wherein at least 9 pulses are delivered between the first target position, the second target position, and the plurality of additional target positions.

6. The method of claim 1, wherein the scan and pulse delivery process comprises a first treatment cycle, the rescan and pulse redelivery process comprises a second treatment cycle, and wherein the method further comprises providing between 10 and 10,000 treatment cycles to treat the retinal tissue of the eye within the first area.

7. The method of claim 1, wherein the scan time of the treatment beam between the first target position and the second target position is between 0.5 milliseconds and 1.5 milliseconds.

8. The method of claim 7, wherein the scan time of the treatment beam between the first target position and the second target position is between 0.9 milliseconds and 1.1 milliseconds.

9. The method of claim 1, wherein the scan comprises a raster scan pattern.

10. The method of claim 1, wherein the duration of each pulse is sufficiently short so that an inner retinal temperature remains below a threshold of coagulative damage.

11. The method of claim 1, further comprising:

defining a treatment boundary via the aiming beam, the treatment boundary separating the retinal tissue to a first area and a second area and the first target position and the second target position being disposed within the first area.

12. The method of claim 11, further comprising:

scanning the treatment beam within the first area; and

delivering the series of pulses at the first and second target positions as the treatment beam is scanned within the first area.

13. The method of claim 11, wherein the treatment boundary comprises a treatment pattern having an array of geometric shapes, and wherein each of the pulses is delivered within one of the geometric shapes.

14. A method for treating an eye of a patient comprising:

directing, via a scanning system, an aiming beam onto retinal tissue of the patient'"'"'s eye;

defining, via the aiming beam, a plurality of target positions;

directing, via the scanning system, a treatment beam onto the retinal tissue of the patient'"'"'s eye; and

delivering, via the treatment beam, a series of pulses onto the retinal tissue at the plurality of target positions to treat the retinal tissue, wherein the treatment beam is scanned between a different target position between each pulse of the treatment beam and the treatment beam is scanned during a relaxation interval of a respective target position such that the retinal tissue at the respective target position relaxes, the relaxation interval comprising at least 190 microseconds, wherein a duration of each pulse is sufficiently short so as to avoid inducing photocoagulation of the retinal tissue that results in visible tissue damage, and wherein the series of pulses directed to each target position induce photoactivation of a therapeutic healing at that position, and wherein the treatment beam is returned to previously treated target positions within the eye to deliver an additional series of pulses after the respective relaxation interval.

15. The method of claim 14, wherein defining the plurality of target positions comprises defining a treatment boundary that separates the retinal tissue to a first area and a second area.