Ambulatory lung assist device with implanted blood pump and oxygenator

• US 9,278,169 B2
• Filed: 03/13/2015
• Issued: 03/08/2016
• Est. Priority Date: 04/06/2012
• Status: Active Grant

• Current Assignee: Heartware,Inc. (Medtronic Plc)
• Original Assignee: Heartware,Inc. (Medtronic Plc)
• Inventors: Strueber, Martin
• Primary Examiner(s): Gedeon, Brian T
• Assistant Examiner(s): TEJANI, ANKIT D
• Application Number:
  US14/657,461
• Publication Number:
  US 20150182681A1
• Time in Patent Office: 361 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/1698 Blood oxygenators with or without heat-exchangers intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/32 Oxygenators without membranes
• CPC Class Codes: A61M 1/3666 Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
• CPC Class Codes: A61M 1/3667 with assisted venous return
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/178 drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
• CPC Class Codes: A61M 60/216 including a rotating member acting on the blood, e.g. impeller
• CPC Class Codes: A61M 60/38 Blood oxygenation

Abstract

The present disclosure provides a system for oxygenating blood. The system may include an implantable blood pump that may draw a supply of blood from the circulatory system of a mammalian subject, such as a human being. The blood pump may provide the supply of blood to an adaptor, where the supply of blood may be supplied to either or both of a first branch or second branch. The first branch may lead to an external blood oxygenator. The oxygenator may oxygenate the blood, and the blood may be returned to the circulatory system of the mammalian subject. The second branch may bypass the oxygenator and may connect to the circulatory system of the mammalian subject. In this regard, while the blood is supplied to the second branch, the oxygenator may be disconnected and blood may be prevented from entering the first branch.

Claims

1. A portable lung assist system comprising:

(a) a blood pump, wherein the blood pump has an outlet and an inlet adapted for communication with the circulatory system of a mammalian subject at an inlet location, and wherein the blood pump can be carried by a subject;

(b) one or more return fittings adapted for communication with the circulatory system of the subject at one or more return locations remote from the inlet location;

(c) an external, portable blood oxygenator having a blood inlet releasably connectable and which is in communication with the outlet of the pump and a blood outlet releasably connectable with one of said return fittings; and

(d) a bypass conduit adapted to connect the outlet of the blood pump in communication with one of said return fittings at least when the oxygenator is disconnected, wherein the portable lung assist system supplements the action of the subject'"'"'s lungs.

2. The system of claim 1 further comprising a blood oxygenator inlet disconnect fitting which is releasably connectable to the outlet of the blood pump and an oxygenator outlet disconnect fitting which is releasably connectable to one of said return fittings, the blood inlet and outlet of the oxygenator are adapted to releasably engage the disconnect fittings.

3. The system as claimed in claim 2 further comprising an adaptor having an inlet connected to the outlet of the blood pump, a first branch connected to the oxygenator inlet disconnect fitting and a second branch connected to the bypass conduit.

4. The system of claim 3, further comprising a valve in the adaptor having a a) normal condition in which blood flow entering the adaptor is directed primarily to the first branch and b) a bypass condition in which blood flow is directed primarily to the second branch.

5. The system of claim 3, wherein an internal diameter of the first branch is different than an internal diameter of the second branch.

6. The system of claim 5, wherein the internal diameter of the first branch is larger than the internal diameter of the second branch.

7. The system of claim 1, further comprising a valve connected in series with the bypass conduit, the valve having a) a normal condition in which flow through the bypass conduit is at least partially blocked and b) a bypass condition in which flow through the bypass conduit is substantially unblocked.

8. The system of claim 7, wherein when the valve is in the normal condition, flow through the bypass conduit is only partially blocked.

9. The system of claim 1, wherein the blood pump is biocompatible.

10. The system of claim 1, wherein the blood pump is selected from a group consisting of an axial-flow blood pump and centrifugal blood pump.

11. The system of claim 1, wherein at least one of the one or more return locations is selected from a group consisting of a right atrium, a right ventricle, and a pulmonary artery.

12. The system of claim 1, wherein the inlet location is a pulmonary artery.

13. The system of claim 1, wherein the bypass conduit is configured to be at least partially disposed within the subject'"'"'s body.

14. The system of claim 1, wherein the blood pump is configured to pump blood out of the subject, towards the blood oxygenator.

15. The system of claim 1, wherein the blood oxygenator is wearable by the subject.

16. The system of claim 1, wherein the blood pump is a ventricular assist device.

17. The system of claim 1, wherein the blood pump is configured for long-term use by the subject.

18. A portable lung assist system comprising:

(a) a blood pump having an outlet and an inlet adapted for communication with the circulatory system of a subject at an inlet location;

(b) one or more return fittings adapted for communication with the circulatory system of the subject at one or more return locations remote from the inlet location;

(c) two external, portable blood oxygenators, wherein each portable oxygenator comprises a blood inlet releasably connectable and which is in communication with the outlet of the pump and a blood outlet releasably connectable and in communication with one of said return fittings.

19. The system of claim 18, wherein the blood pump is configured to be implanted in the subject.

20. The system of claim 18, wherein the blood pump is configured to be carried by the subject.

21. The system of claim 18, wherein the system is configured to pump blood through both oxygenators.

22. A portable lung assist system comprising:

(a) a blood pump having an outlet and an inlet adapted for communication with the circulatory system of a subject at an inlet location;

(b) one or more return fittings adapted for communication with the circulatory system of the subject at one or more return locations remote from the inlet location; and

(c) an external, portable blood oxygenator having a blood inlet releasably connectable and in communication with the outlet of the blood pump and a blood outlet releasably connectable and in communication with one of said return fittings.

23. The system of claim 22, wherein the blood pump is configured to be implanted in the subject.

24. The system of claim 22, wherein the blood pump is configured to be carried by the subject.

25. The system of claim 22, further comprising a bypass conduit adapted to connect the outlet of the blood pump in communication with one of said return fittings at least when the oxygenator is disconnected.

26. The system of claim 22, further comprising a second external, portable blood oxygenator having a blood inlet releasably connectable to and in communication with the outlet of the pump and a blood outlet releasably connectable in communication with one of said return fittings.

27. A method of providing respiratory assistance to a subject comprising:

(a) directing blood from an inlet location in the circulatory system of the subject through a blood pump, out of the subject, through a first and second external, portable oxygenator and back to the circulatory system;

(b) disconnecting the first external, portable oxygenator;

(c) directing blood through the blood pump, and through the second external, portable oxygenator, back to the circulatory system; and

(d) reconnecting either (i) the first external, portable oxygenator from (a), or (ii) a different first external, portable oxygenator.

28. The method of claim 27, wherein (b), (c) and (d) are performed so that blood continuously flows through the pump.

29. The method of claim 27, wherein in (c), the blood is directed back to the pulmonary artery of the subject.

30. The method of claim 29, wherein in (a), the blood is directed back to the pulmonary artery of the subject.

31. The method of claim 27, wherein (a) further comprises simultaneously directing blood through a bypass conduit and back to the circulatory system.

32. The method of claim 31, wherein during (a), blood passes through the oxygenator at a first rate and blood passes through a bypass conduit at a second rate less than the first rate.