Substituted-quinoxaline-type piperidine compounds and the uses thereof

• US 9,278,967 B2
• Filed: 07/14/2014
• Issued: 03/08/2016
• Est. Priority Date: 08/31/2007
• Status: Active Grant

• Current Assignee: Purdue Pharma L.P.
• Original Assignee: Purdue Pharma L.P., Shionogi & Co., Ltd.
• Inventors: Fuchino, Kouki, Goehring, R. Richard, Matsumura, Akira, Shao, Bin, Taoda, Yoshiyuki, Tsuno, Naoki, Whitehead, John William Frank, Yao, Jiangchao
• Primary Examiner(s): Cordero Garcia, Marcela M
• Assistant Examiner(s): YANG, KAIPEEN E
• Application Number:
  US14/331,034
• Publication Number:
  US 20150141643A1
• Time in Patent Office: 603 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 31/498 Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• CPC Class Codes: A61P 1/10 Laxatives
• CPC Class Codes: A61P 1/12 Antidiarrhoeals
• CPC Class Codes: A61P 1/14 Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
• CPC Class Codes: A61P 11/14 Antitussive agents
• CPC Class Codes: A61P 13/02 of urine or of the urinary tract, e.g. urine acidifiers
• CPC Class Codes: A61P 13/06 Anti-spasmodics
• CPC Class Codes: A61P 13/10 of the bladder
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/08 Antiepileptics; Anticonvulsants
• CPC Class Codes: A61P 25/16 Anti-Parkinson drugs
• CPC Class Codes: A61P 25/22 Anxiolytics
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: A61P 25/30 for treating abuse or dependence
• CPC Class Codes: A61P 25/36 Opioid-abuse
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/00 Drugs for disorders of the blood or the extracellular fluid
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07D 401/04 : directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 401/14 : containing three or more hetero rings
• CPC Class Codes: C07D 451/04 : with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
• CPC Class Codes: C07D 451/14 : containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
• CPC Class Codes: C07D 471/08 : Bridged systems
• CPC Class Codes: C07D 471/14 : Ortho-condensed systems
• CPC Class Codes: C07D 487/04 : Ortho-condensed systems
• CPC Class Codes: C07D 498/08 : Bridged systems
• CPC Class Codes: C07D 519/00 : Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound.

Claims

1. A method for treating pain in an animal in need thereof, comprising administering to the animal an effective amount of a compound of Formula (I) or (II) or a pharmaceutically acceptable salt of the compound of Formula (I) or (II):

2. The method for treating pain of claim 1, wherein Y₁ is O.

3. The method for treating pain of claim 2, wherein Q is fused benzo or fused pyridino.

4. The method for treating pain of claim 3, wherein a is 0.

5. The method for treating pain of claim 3, wherein A and B are each —

H.

6. The method for treating pain of claim 3, wherein A and B together form a bridge such that the bridged-piperidine is:

7. The method for treating pain of claim 6, wherein h is 0 and R₁ is:

8. The method for treating pain of claim 1, wherein the pain is acute pain.

9. The method for treating pain of claim 1, wherein the pain is inflammatory pain.

10. The method for treating pain of claim 1, wherein the pain is neuropathic pain.

11. A method for treating pain in an animal in need thereof, comprising administering to the animal an effective amount of a compound of Formula (IIb) or (IIc) or a pharmaceutically acceptable salt of the compound of Formula (IIb) or (IIc):

12. The method for treating pain of claim 11, wherein a is 0.

13. The method for treating pain of claim 11, wherein the pain is acute pain.

14. The method for treating pain of claim 11, wherein the pain is inflammatory pain.

15. The method for treating pain of claim 11, wherein the pain is neuropathic pain.

16. A method for treating pain in an animal in need thereof, comprising administering to the animal an effective amount of a compound which is:

17. The method for treating pain of claim 16, wherein the compound is:

18. The method for treating pain of claim 16, wherein the pain is acute pain.

19. The method for treating pain of claim 16, wherein the pain is inflammatory pain.

20. The method for treating pain of claim 16, wherein the pain is neuropathic pain.