Functionally-modified oligonucleotides and subunits thereof
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Abstract
Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects.
133 Citations
16 Claims
- 1. A compound having the structure of Formula (I):
Specification