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Optimization of nucleation and crystallization for lyophilization using gap freezing

  • US 9,279,615 B2
  • Filed: 01/17/2014
  • Issued: 03/08/2016
  • Est. Priority Date: 09/28/2010
  • Status: Expired due to Fees
First Claim
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1. A lyophilization device comprising:

  • a plurality of heat sinks that individually have a heat sink surface in thermal communication with a refrigerant, at least one of said heat sinks being disposed above another to thereby form upper and lower heat sinks;

    wherein the lower heat sink surface is disposed between the upper and lower heat sinks;

    a tray carrying a tray surface disposed between the upper heat sink and a lower heat sink surface; and

    a thermal insulator formed extending between the container on the tray and the lower heat sink, wherein the thermal insulator is a gas having a thermal conductivity of less than about 0.2 W/mK at 25°

    C.

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