Apparatus, method, system for the determination of the aggregation rate of red blood cells
First Claim
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1. An apparatus for determining the aggregation rate of red blood cells, comprising:
- a) a hydraulic circuit having a pump for transporting a blood sample portion comprising red blood cells that have aggregated;
b) a reading cell container operationally connected to the hydraulic circuit configured for receipt of the blood sample portion;
c) a light emitter source positioned about the reading cell to pass light through the blood sample portion;
d) an optical receiver positioned opposite the light emitter source and about the reading cell to detect light passing through the blood sample portion;
e) a disruption mechanism connected to the reading cell container for disruption of the red blood cell aggregates within the blood sample portion to assist in recording a disruption rate; and
f) a main controller operationally connected to the disruption mechanism, the main controller configured to activate the disruption mechanism for the disruption of the red blood cell aggregates within the blood sample portion until light detected stops decreasing, indicating the disruption of aggregates within the blood sample portion,whereby, in a method of using the apparatus, after the disruption mechanism is stopped, the main controller records an aggregation rate of the red blood cells of the blood sample portion for a predetermined time based upon detected light variation.
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Abstract
The present invention generally relates to an apparatus, method, system for the determination of the aggregation rate of red blood cells. More specifically, the invention concerns a method, system, and the relative apparatus used to determine the aggregation rate of red blood cells, and other parameters related to these, such as viscosity, deformability, elasticity, density, in the field of in vitro medical analyses, using optical systems after or during inducted forces for red blood cell disruption and redistribution generated by ultrasound waves.
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Citations
20 Claims
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1. An apparatus for determining the aggregation rate of red blood cells, comprising:
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a) a hydraulic circuit having a pump for transporting a blood sample portion comprising red blood cells that have aggregated; b) a reading cell container operationally connected to the hydraulic circuit configured for receipt of the blood sample portion; c) a light emitter source positioned about the reading cell to pass light through the blood sample portion; d) an optical receiver positioned opposite the light emitter source and about the reading cell to detect light passing through the blood sample portion; e) a disruption mechanism connected to the reading cell container for disruption of the red blood cell aggregates within the blood sample portion to assist in recording a disruption rate; and f) a main controller operationally connected to the disruption mechanism, the main controller configured to activate the disruption mechanism for the disruption of the red blood cell aggregates within the blood sample portion until light detected stops decreasing, indicating the disruption of aggregates within the blood sample portion, whereby, in a method of using the apparatus, after the disruption mechanism is stopped, the main controller records an aggregation rate of the red blood cells of the blood sample portion for a predetermined time based upon detected light variation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An apparatus for determining the aggregation rate of red blood cells, comprising:
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a) a hydraulic circuit for transporting a blood sample portion comprising aggregated red blood cells; b) a reading cell container configured to receive the blood sample portion from the hydraulic circuit; c) a light emitter source to pass light through the blood sample portion while the blood sample portion is in the reading cell container; d) an optical receiver positioned to detect light passing from the light emitter source through the blood sample portion while the blood sample portion is in the reading cell container; e) a disruption mechanism connected to the reading cell container to disrupt the aggregated red blood cells within the blood sample portion while the blood sample portion is in the reading cell container; and f) a main controller configured to selectively activate the disruption mechanism and record an aggregation rate of the red blood cells in the blood sample portion based upon detected light variation. - View Dependent Claims (17, 18, 19)
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20. An apparatus for determining the aggregation rate of red blood cells, comprising:
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a) a reading cell container configured to receive a blood sample portion comprising aggregated red blood cells from a hydraulic circuit; b) a light emitter source to pass light through the blood sample portion while the blood sample portion is in the reading cell container; c) an optical receiver positioned to detect light passing from the light emitter source through the blood sample portion while the blood sample portion is in the reading cell container; d) a disruption mechanism connected to the reading cell container to disrupt the aggregated red blood cells within the blood sample portion while the blood sample portion is in the reading cell container; and e) a main controller configured to record an aggregation rate of the red blood cells in the blood sample portion based upon detected light variation.
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Specification