Applicator for endoscopic treatment of biliary disease

• US 9,282,968 B2
• Filed: 11/22/2010
• Issued: 03/15/2016
• Est. Priority Date: 11/30/2007
• Status: Expired due to Fees

• Current Assignee: Treus Medical, Inc.
• Original Assignee: Treus Medical, Inc.
• Inventors: Van Dam, Jacques, Milroy, J. Craig, Ohline, R. Matthew
• Primary Examiner(s): Bosworth, Kami A
• Assistant Examiner(s): LEE, BRANDY SCOTT
• Application Number:
  US12/951,803
• Publication Number:
  US 20110071350A1
• Time in Patent Office: 1,940 Days
• Field of Search: 604/8, 604/540, 604/264, 604/275
• US Class Current: 1/1
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 17/1114 of the digestive tract, e.g. bowels or oesophagus
• CPC Class Codes: A61B 2017/00278 Transorgan operations, e.g. transgastric
• CPC Class Codes: A61B 2017/1139 Side-to-side connections, e.g. shunt or X-connections
• CPC Class Codes: A61F 2/04 Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts A61F2/18, A61F2/20 take precedence; devices, other than stent-grafts, providing patency to, or preventing collapsing of, tubular structures of the body other than stent-grafts, e.g. stents A61F2/82; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95
• CPC Class Codes: A61F 2/064 with special features to facilitate anastomotic coupling anastomosis of natural blood vessels A61B17/11
• CPC Class Codes: A61F 2/24 Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
• CPC Class Codes: A61F 2/2493 Transmyocardial revascularisation [TMR] devices
• CPC Class Codes: A61F 2002/041 Bile ducts
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2250/0039 differing in diameter
• CPC Class Codes: A61M 2025/0233 specifically adapted for attaching to a body wall by means which are on both sides of the wall, e.g. for attaching to an abdominal wall
• CPC Class Codes: A61M 2025/1072 having balloons with two or more compartments
• CPC Class Codes: A61M 25/1002 characterised by balloon shape A61M25/1006, A61M25/1009 take precedence
• CPC Class Codes: A61M 27/008 pre-shaped, for use in the urethral or ureteral tract
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104

Abstract

A device for treating biliary disease includes a component configured for deployment to a lumen of a gallbladder or gallbladder duct. The component has a proximal end and a distal end with a lumen extending therethrough and a fluid or gas delivery apparatus at its distal end.

Claims

1. An applicator for endoscopic delivery to treat biliary disease, comprising:

an elongated member having a proximal end and a distal end adapted to be delivered transluminally from an exterior surface of a gallbladder to an interior lumen of the gallbladder without use of a common bile duct, the elongated member having a length adapted for delivery through a mammalian esophagus, stomach and duodenum, and an outer diameter smaller than a mammalian esophagus;

a lumen positioned within the elongated member with an aperture at the distal end of the elongated member, wherein the lumen within the elongated member extends a length of the elongated member and is sized to deliver at least one of a guiding element or a stirring element through the aperture at the distal end of the elongated member;

one or more material delivery apertures positioned at the distal end of the elongated member and sharing a coplanar relationship to another of the one or more material delivery apertures, wherein the one or more material delivery apertures configured to deliver a material to the interior lumen of the gallbladder or a gallbladder duct, wherein the one or more delivery apertures are configured to deliver the material in a 360 degree radial pattern, wherein the one or more material delivery apertures are in fluid communication with the lumen within the elongated member, and wherein the one or more material delivery apertures have a smaller diameter than the aperture of the lumen within the elongated member; and

a valve positioned within the lumen within the elongated member, wherein the valve is configured to control an amount and a timing of the delivery of the material to the interior lumen of the gallbladder.

2. The applicator of claim 1, wherein the distal end has an angular orientation relative to the length of the elongated member.

3. The applicator of claim 1, wherein the distal end is configured to deliver the material with at least one of a sharp stream and a cone shape.

4. The applicator of claim 1, wherein the distal end has an articulating member.

5. The applicator of claim 1, further comprising a vacuum element configured to apply a vacuum to the gallbladder or the gallbladder duct.

6. The applicator of claim 1, wherein the distal end is configured to apply an adhesive to the interior lumen of the gallbladder.

7. The applicator of claim 1, wherein the applicator is configured for deployment by an endoscope.

8. The applicator of claim 1, wherein the applicator is configured for deployment using at least one of a needle, a guidewire, or a guidance catheter.

9. The applicator of claim 1, wherein the lumen within the elongated member is configurable to provide restrictable fluid flow.

10. The applicator of claim 1, further comprising one or more fluid control components.

11. The applicator of claim 1, wherein the valve comprises a user-controllable flow-restrictor valve.

12. The applicator of claim 1, wherein the valve comprises a one-way valve configured to only allow the material to flow therethrough toward the one or more material delivery apertures.

13. The applicator of claim 1, wherein the elongated member is flexible and wherein the elongated member is an elongate tube configured to extend into the gastrointestinal tract.

14. A kit for treating biliary disease comprising:

a device comprising;

an elongated member having a proximal end and a distal end adapted to be delivered transluminally from an exterior surface of a gallbladder to an interior lumen of the gallbladder;

a lumen positioned within the elongated member with an aperture at the distal end of the elongated member, wherein the lumen within the elongated member extends a length of the elongated member and is sized to deliver at least one of a guiding element or a stirring element through the aperture at the distal end of the elongated member;

one or more material delivery apertures positioned at the distal end of the elongated member and sharing a coplanar relationship to another of the one or more material delivery apertures, wherein the one or more material delivery apertures configured to deliver a material to the interior lumen of the gallbladder or a gallbladder duct, wherein the one or more delivery apertures are configured to deliver the material in a 360 degree radial pattern, wherein the one or more material delivery apertures are in fluid communication with the lumen within the elongated member, and wherein the one or more material delivery apertures have a smaller diameter than the aperture of the lumen within the elongated member;

a valve positioned within the lumen within the elongated member, wherein the valve is configured to control an amount and a timing of the delivery of the material to the interior lumen of the gallbladder;

an ablation device configured to ablate tissue of the gallbladder; and

the material to be delivered to the gallbladder or the gallbladder duct.

15. The kit of claim 14, wherein the material comprises a sclerosing agent, an antibiotic, an inflammatory agent, an anti-inflammatory agent, a biocompatible gel, or a biocompatible foam.

16. The kit of claim 14, further comprising a needle, a guidewire, or a guidance catheter configured to deploy the device.

17. The kit of claim 14, further comprising a temperature measurement instrument.

18. The kit of claim 14, further comprising a pressure measurement instrument.

19. An applicator for endoscopic delivery to treat biliary disease, comprising:

an elongated member having a proximal end and a distal end adapted to be delivered transluminally from an exterior surface of a gallbladder to an interior lumen of the gallbladder without use of a common bile duct, the elongated member having a length adapted for delivery through a mammalian esophagus, stomach and duodenum, and an outer diameter smaller than a mammalian esophagus;

a lumen positioned within the elongated member with an aperture at the distal end of the elongated member, wherein the lumen within the elongated member extends a length of the elongated member and is sized to deliver at least one of a guiding element or a stirring element through the aperture at the distal end of the elongated member;

a nozzle coupled to the distal end of the elongated member, the nozzle comprising one or more material delivery apertures and configured to deliver a material to the interior lumen of the gallbladder or a gallbladder duct, wherein the one or more delivery apertures is configured to deliver the material in a 360 degree radial pattern, wherein the nozzle and the one or more material delivery apertures are in fluid communication with the lumen within the elongated member, and wherein the one or more material delivery apertures have a smaller diameter than the aperture of the lumen within the elongated member; and

a valve positioned within the lumen within the elongated member, wherein the valve is configured to control an amount and a timing of the delivery of the material to the interior lumen of the gallbladder.