Sublingual films
First Claim
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1. A pharmaceutical composition in unit dosage form formulated for sublingual administration, wherein said unit dosage form is a film comprising a first portion comprising apomorphine hydrochloride and a second portion comprising from 10±
- 2 to 50±
5% (w/w) of a pH neutralizing agent that is an organic base having a pKa of 5±
2, wherein said unit dosage form comprises from 2 to 60 mg of apomorphine hydrochloride.
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Abstract
The invention features sublingual film formulations of dopamine agonists and methods of treating Parkinson'"'"'s disease, tremors, restless leg syndrome, sexual dysfunction, and depressive disorders therewith.
70 Citations
29 Claims
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1. A pharmaceutical composition in unit dosage form formulated for sublingual administration, wherein said unit dosage form is a film comprising a first portion comprising apomorphine hydrochloride and a second portion comprising from 10±
- 2 to 50±
5% (w/w) of a pH neutralizing agent that is an organic base having a pKa of 5±
2, wherein said unit dosage form comprises from 2 to 60 mg of apomorphine hydrochloride. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
- 2 to 50±
Specification