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Single-use manifold and sensors for automated, aseptic transfer of solutions in bioprocessing applications

  • US 9,283,521 B2
  • Filed: 12/05/2005
  • Issued: 03/15/2016
  • Est. Priority Date: 06/14/2002
  • Status: Active Grant
First Claim
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1. A manifold system for biotechnology uses, comprising:

  • a manifold unit which is pre-sterilized and disposable so as to be adapted for single-time usage, including;

    at least one length of tubing having at least one inlet end portion, at least one outlet end portion, an outside surface, and an inside surface which is sterilized for passage of a biotechnology fluid therethrough;

    at least one single-use container operatively connecting to said length of tubing at least one pre-sterilized, calibrated and disposable electrical conductivity sensor adapted for single-time usage;

    the sensor has a memory component capable of storing data, the memory component including a sensor-specific Cell Constant (K) assigned to that specific sensor during calibration of the sensor;

    the memory component further includes a sensor-specific temperature offset assigned to that specific sensor during calibration of the sensor, wherein said temperature offset was determined during manufacture employing a calibration solution, including determining the actual temperature (Tref) value of the calibration solution, using the specific pre-calibrated sensor to measure the temperature (Tsen) value of the calibration solution, and mathematically combining said Tref and said Tsen into said sensor-specific temperature offset; and

    wherein the disposable electrical conductivity sensor senses electrical conductivity of the biotechnology fluid.

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