Single-use manifold and sensors for automated, aseptic transfer of solutions in bioprocessing applications
First Claim
1. A manifold system for biotechnology uses, comprising:
- a manifold unit which is pre-sterilized and disposable so as to be adapted for single-time usage, including;
at least one length of tubing having at least one inlet end portion, at least one outlet end portion, an outside surface, and an inside surface which is sterilized for passage of a biotechnology fluid therethrough;
at least one single-use container operatively connecting to said length of tubing at least one pre-sterilized, calibrated and disposable electrical conductivity sensor adapted for single-time usage;
the sensor has a memory component capable of storing data, the memory component including a sensor-specific Cell Constant (K) assigned to that specific sensor during calibration of the sensor;
the memory component further includes a sensor-specific temperature offset assigned to that specific sensor during calibration of the sensor, wherein said temperature offset was determined during manufacture employing a calibration solution, including determining the actual temperature (Tref) value of the calibration solution, using the specific pre-calibrated sensor to measure the temperature (Tsen) value of the calibration solution, and mathematically combining said Tref and said Tsen into said sensor-specific temperature offset; and
wherein the disposable electrical conductivity sensor senses electrical conductivity of the biotechnology fluid.
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0 Petitions
Accused Products
Abstract
Presteralized manifolds are provided which are designed for sterile packaging and single-use approaches. Disposable tubing and flexible-wall containers are assembled via aseptic connectors. These manifolds interact with valves and pumping equipment which can be operated by a controller which provides automated and accurate delivery of biotechnology fluid. The manifold also being used in conjunction with one or more conductivity sensors used to measure the conductivity of the biotechnology fluid. Such sensors interact with the controller or are connected to a separate user interface. The combination of disposable tubing, flexible-wall containers, aseptic connectors, manifold, controller, and conductivity sensors provides an aseptic environment while avoiding or reducing cleaning and quality assurance procedures.
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Citations
30 Claims
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1. A manifold system for biotechnology uses, comprising:
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a manifold unit which is pre-sterilized and disposable so as to be adapted for single-time usage, including; at least one length of tubing having at least one inlet end portion, at least one outlet end portion, an outside surface, and an inside surface which is sterilized for passage of a biotechnology fluid therethrough; at least one single-use container operatively connecting to said length of tubing at least one pre-sterilized, calibrated and disposable electrical conductivity sensor adapted for single-time usage; the sensor has a memory component capable of storing data, the memory component including a sensor-specific Cell Constant (K) assigned to that specific sensor during calibration of the sensor; the memory component further includes a sensor-specific temperature offset assigned to that specific sensor during calibration of the sensor, wherein said temperature offset was determined during manufacture employing a calibration solution, including determining the actual temperature (Tref) value of the calibration solution, using the specific pre-calibrated sensor to measure the temperature (Tsen) value of the calibration solution, and mathematically combining said Tref and said Tsen into said sensor-specific temperature offset; and wherein the disposable electrical conductivity sensor senses electrical conductivity of the biotechnology fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A manifold system for biotechnology uses, wherein said system is for automated, aseptic fluid transfer, comprising:
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a manifold unit which is pre-sterilized and disposable so as to be adapted for single-time usage, including; at least one length of tubing having at least one inlet end portion, at least one outlet end portion, an outside surface, and an inside surface which is sterilized for passage of a biotechnology fluid therethrough; at least one single-use container operatively connecting to said length of tubing; said outlet end portion of the tubing operably connects with said single-use container; at least one pre-sterilized, calibrated and disposable electrical conductivity sensor adapted for single-time usage, the sensor having a memory component capable of storing data, the memory component including a sensor-specific Cell Constant (K) assigned to that specific sensor during calibration of the sensor; the memory component further includes a sensor-specific temperature offset assigned to that specific sensor during calibration of the sensor, wherein said temperature offset was determined during manufacture employing a calibration solution, including determining the actual temperature (Tref) value of the calibration solution, using the specific pre-calibrated sensor to measure the temperature (Tsen) value of the calibration solution, and mathematically combining said Tref and said Tsen into said sensor-specific temperature offset; and wherein the disposable electrical conductivity sensor senses electrical conductivity of the biotechnology fluid. - View Dependent Claims (28, 29, 30)
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Specification