Endoprosthesis having a non-fouling surface

• US 9,284,409 B2
• Filed: 07/17/2008
• Issued: 03/15/2016
• Est. Priority Date: 07/19/2007
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Edelman, Peter, Robaina, Samuel
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): Mathew, Seema
• Application Number:
  US12/174,752
• Publication Number:
  US 20090149942A1
• Time in Patent Office: 2,798 Days
• Field of Search: 623/1.15, 623/1.42, 424/2.24
• US Class Current: 1/1
• CPC Class Codes: A61L 31/088 Other specific inorganic materials not covered by A61L31/084 or A61L31/086
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C08G 65/3322 acyclic
• CPC Class Codes: C08G 65/33337 cyclic
• CPC Class Codes: C08L 2203/02 for biomedical use
• CPC Class Codes: C08L 71/02 Polyalkylene oxides

Abstract

In embodiments, medical devices have a surface that includes a catalytic material, and a non-fouling material attached to the surface. The non-fouling material can be released from the surface, for example, by cleavage of a bond connecting the material to the surface. The bond can be a chemical bond, such as a covalent bond.

Claims

1. An endoprosthesis, comprising:

a surface comprising a catalytic material, and

a non-fouling material attached to the surface, wherein the material reduces adsorption of a protein to the surface and has a preferentially cleavable link connecting the material to the surface.

2. The endoprosthesis of claim 1, wherein the catalytic material catalyzes decomposition of H₂O₂.

3. The endoprosthesis of claim 1, wherein the catalytic material is a ceramic.

4. The endoprosthesis of claim 1, wherein the catalytic material comprises iridium oxide.

5. The endoprosthesis of claim 1, wherein the catalytic material is selected from titanium nitrate, and platinum activated carbon.

6. The endoprosthesis of claim 1, wherein the non-fouling material comprises a hydrophilic compound.

7. The endoprosthesis of claim 6, wherein the compound comprises a PEG.

8. The endoprosthesis of claim 7, wherein the PEG has a molecular weight of about 1,000 to about 50,000.

9. The endoprosthesis of claim 1, wherein the non-fouling material is releasable from the surface.

10. The endoprosthesis of claim 1, wherein the link is hydrolysable.

11. The endoprosthesis of claim 1, wherein the link is an ester bond.

12. The endoprosthesis of claim 1, wherein the non-fouling material forms a layer.

13. The endoprosthesis of claims 1, wherein the non-fouling material comprises a first block and a second block that is between the first block and the surface.

14. The endoprosthesis of claim 13, wherein the first block has a primary function of repelling proteins.

15. The endoprosthesis of claim 13, wherein the second block has a primary function of linkage as to connect the first block to the surface.

16. The endoprosthesis of claim 13, wherein the first and second blocks are connected by a preferentially cleavable link.

17. The endoprosthesis of claim 16, wherein the second block and the surface are connected by a preferentially cleavable link.

18. The endoprosthesis of claim 16, wherein the link is hydrolysable.

19. The endoprosthesis of claim 13, wherein the first block comprises a PEG and the second block comprises an aminosilane.

20. The endoprosthesis of claim 18, wherein the first block comprises a PEG and the second block comprises an aminosilane.

21. The endoprosthesis of claim 18, wherein the first block comprises a PEG and the second block comprises an endothelial cell binding agent.

22. The endoprosthesis of claim 20, wherein the second block further comprises an endothelial cell binding agent.

23. The endoprosthesis of claim 21, wherein the endothelial cell binding agent comprises an RGD peptide fragment.

24. A method of forming an endoprosthesis, comprising:

coating a surface with a temporary non-fouling layer, the surface comprising a catalytic material, the layer reducing adsorption of a protein to the surface and allowing H₂O₂ to the surface.

25. The method of claim 24, wherein the surface comprises IROX.

26. The method of claim 24, wherein the non-fouling layer comprises a hydrophilic polymer.

27. The method of claim 24, further comprising modifying the surface with an aminosilane before coating the surface with the layer.

28. The method of claim 27, wherein the aminosilane is APTES.

29. The method of claim 27, wherein the layer comprises a hydrophilic polymer.

30. The method of claim 26, wherein the polymer has a hydrolysable link connecting the polymer to the surface.

31. The method of claim 29, wherein the polymer has a hydrolysable link connecting the polymer to the aminosilane.

32. The method of claim 24, further comprising modifying the surface with an endothelial cell binding agent before coating the surface with the layer.

33. The method of claim 32, wherein the endothelial cell binding agent comprises an RGD peptide segment.

34. The method of claim 32, wherein the layer comprises a hydrophilic polymer.

35. The method of claim 34, wherein the polymer has a hydrolysable link connecting the polymer to the endothelial cell binding agent.