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Cellular arrays and methods of detecting and using genetic disorder markers

  • US 9,284,610 B2
  • Filed: 11/14/2012
  • Issued: 03/15/2016
  • Est. Priority Date: 10/28/1998
  • Status: Expired due to Fees
First Claim
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1. A composition suitable for detecting the presence of cancerous cells in a human breast tissue specimen, said composition comprising nucleic acids, wherein said nucleic acids consist of (i) a labeled probe suitable for detecting expression of PDGF-β

  • , said probe obtained by PCR screening of a human genomic library and suitable for detecting expression of PDGF- β

    in the human breast cancer specimen;

    (ii) a labeled locus specific probe for chromosomal region 7q31;

    (iii) a labeled locus specific probe for chromosomal region 8p11-p12; and

    (iv) a labeled locus specific probe for chromosomal region 10q25-26, wherein probes (ii), (iii), and (iv) are suitable for detecting their target chromosomal regions in the human breast cancer specimen, and wherein probes (i), (ii), (iii), and (iv) are labeled with a fluorescent dye.

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