Antimicrobial compositions and related methods of use

• US 9,288,981 B2
• Filed: 05/15/2014
• Issued: 03/22/2016
• Est. Priority Date: 04/27/2009
• Status: Active Grant

• Current Assignee: Jeneil Biosurfactant Company, LLC
• Original Assignee: Jeneil Biosurfactant Company, LLC
• Inventors: Gandhi, Niranjan Ramanlal, Skebba, Victoria Palmer, Strobel, Gary A.
• Primary Examiner(s): Kim, Taeyoon
• Application Number:
  US14/279,075
• Publication Number:
  US 20150073048A1
• Time in Patent Office: 677 Days
• US Class Current: 1/1
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/08 containing solids as carriers or diluents
• CPC Class Codes: A01N 25/18 Vapour or smoke emitting compositions with delayed or sustained release
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 25/34 Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 35/02 containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
• CPC Class Codes: A01N 35/04 containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
• CPC Class Codes: A01N 37/02 Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/06 Unsaturated carboxylic acids or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/12 containing the group , wherein Cn means a carbon skeleton not containing a ring; Thio analogues thereof
• CPC Class Codes: A01N 37/14 containing the group; Thio analogues thereof
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 43/16 with oxygen as the ring hetero atom
• CPC Class Codes: A01N 63/30 Microbial fungi; Substances produced thereby or obtained therefrom
• CPC Class Codes: A23B 4/20 Organic compounds; Microorganisms; Enzymes
• CPC Class Codes: A23B 7/154 Organic compounds; Microorganisms; Enzymes
• CPC Class Codes: A23B 9/26 Organic compounds; Microorganisms; Enzymes
• CPC Class Codes: A23L 3/3508 containing carboxyl groups
• CPC Class Codes: A23L 3/3517 Carboxylic acid esters
• CPC Class Codes: A23L 3/3562 : Sugars; Derivatives thereof
• CPC Class Codes: A23V 2002/00 : Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A61K 45/06 : Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61Q 11/02 : Preparations for deodorising, bleaching or disinfecting dentures
• CPC Class Codes: A61Q 19/00 : Preparations for care of the skin
• CPC Class Codes: C12N 1/14 : Fungi culture of mushrooms A01G18/00; as new plants A01H15/00; Culture media therefor
• CPC Class Codes: C12N 1/145 : Fungal isolates
• CPC Class Codes: C12P 7/00 : Preparation of oxygen-containing organic compounds
• CPC Class Codes: C12R 2001/645 : Fungi ; Processes using fungi
• CPC Class Codes: D06M 16/00 : Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
• CPC Class Codes: Y02E 50/10 : Biofuels, e.g. bio-diesel

Abstract

Antimicrobial compositions comprising one or more compound components generally recognized as safe for human consumption, and related methods of use, such compositions and methods as can be employed in a wide range of agricultural, industrial, building, pharmaceutical and/or personal care products and applications.

Claims

1. A method of affecting microbial activity, said method comprising providing a composition comprising a naturally-derived C₂-C₅ acid component, a naturally-derived C₂-C₅ acid ester component, a naturally-derived C₃-C₅ ketone component, and at least two naturally-derived C₂-C₅ components isolatable from a volatile by-product of an isolated culture of Muscodor crispans grown on potato dextrose agar, providing said composition is absent naphthalene and azulene derivative compounds;

and contacting at least one of a microbe and a substrate capable of supporting microbial activity with said composition, said composition in an amount at least partially sufficient to affect microbial activity.

2. The method of claim 1 wherein said substrate is selected from plant components and of articles of manufacture.

3. The method of claim 2 wherein said substrate is selected from a seed, a plant surface component, a fruit, a vegetable and a nut.

4. The method of claim 3 wherein said substrate is selected from plant stems and foliage.

5. The method of claim 3 wherein said substrate is selected from pre-harvest fruits, vegetables and nuts, and post-harvest fruits, vegetables and nuts.

6. The method of claim 2 wherein said article is selected from a packaging product, a personal care product, product processing equipment, a medical apparatus and a dental apparatus.

7. The method of claim 6 wherein said packaging product is a film.

8. The method of claim 2 wherein said article comprises granules of a solid carrier component.

9. The method of claim 8 wherein said carrier component comprises a clay.

10. The method of claim 9 wherein said clay is a bentonite clay.

11. The method of claim 1 wherein said acid component is selected from isobutyric acid, propanoic acid and combinations thereof.

12. The method of claim 1 wherein said composition comprises a rhamnolipid component.

13. The method of claim 1 wherein said contact is selected from direct contact of said composition and upon at least partial vaporization of said composition.

14. The method of claim 3 wherein said contact is directly with a said microbe.

15. A method of affecting microbial activity, said method comprising providing a composition comprising 8-10 components selected from naturally-derived C₂-C₅ alcohols components, naturally-derived C₃-C₅ ketones components, naturally-derived C₂-C₅ aldehydes components, naturally-derived C₂-C₅ acids components and naturally-derived C₂-C₅ acid esters components, each said component isolatable from an isolated culture of M. crispans grown on potato dextrose agar, each said component of said composition generally recognized as safe for human consumption under Chapter 21 of the United States Code of Federal Regulations;

and contacting at least one of a microbe and a substrate capable of supporting microbial activity with said composition, said composition in an amount at least partially sufficient to affect microbial activity.

16. The method of claim 15 wherein said substrate is selected from plant components and articles of manufacture.

17. The method of claim 16 wherein said substrate is selected from a seed, a plant surface component, a fruit, a vegetable and a nut.

18. The method of claim 17 wherein said substrate is selected from plant stems and foliage.

19. The method of claim 17 wherein said substrate is selected from pre-harvest fruits, vegetables and nuts, and post-harvest fruit, vegetables and nuts.

20. The method of claim 15 wherein one of said isolatable acid components is isobutyric acid.

21. The method of claim 20 wherein propanoic acid is at least in part substituted for said isobutyric acid.

22. The method of claim 15 wherein said composition comprises a rhamnolipid component.

23. The method of claim 15 wherein said contact is selected from direct contact of said composition and upon at least partial vaporization of said composition.

24. A method of affecting microbial activity, said method comprising providing a composition comprising an acid component selected from C₂-C₅ acids, acid salts and combinations thereof, a C₂-C₅ acid ester component, a C₃-C₅ ketone component, and at least two C₂-C₅ components isolatable from a volatile by-product of an isolated culture of Muscodor crispans grown on potato dextrose agar, providing said composition is absent naphthalene and azulene derivative compounds;

and contacting at least one of a microbe and a substrate capable of supporting microbial activity with said composition, said composition in an amount at least partially sufficient to affect microbial activity.

25. The method of claim 24 wherein said substrate is selected from plant components and articles of manufacture.

26. The method of claim 25 wherein said article is selected from packaging products and articles comprising granules of a solid carrier component.

27. The method of claim 26 wherein said carrier component comprises a clay.

28. The method of claim 27 wherein said clay component is a bentonite clay.

29. The method of claim 24 wherein said acid component is selected from isobutyric acid, salts of isobutyric acid and combinations thereof.

30. The method of claim 29 wherein said acid component is selected from isobutyric acid and the potassium and ammonium salts thereof.

31. The method of claim 24 wherein said ester component is selected from esters of acetic acid, propanoic acid and isobutyric acid and combinations of said esters.

32. The method of claim 24 comprising a rhamnolipid component.

33. The method of claim 24 wherein said contact is selected from direct contact of said composition and upon at least partial vaporization of said composition.