Apparatus and method for measuring blood pressure

• US 9,289,138 B2
• Filed: 11/18/2009
• Issued: 03/22/2016
• Est. Priority Date: 11/18/2008
• Status: Expired due to Fees

• Current Assignee: SunTech Medical, Inc. (Halma PLC)
• Original Assignee: SunTech Medical, Inc. (Halma PLC)
• Inventors: Chowienczyk, Philip Jan, Brett, Sally Emma, Guilcher, Antoine Yves Marie
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): Alter, Mitchell E
• Application Number:
  US13/129,017
• Publication Number:
  US 20110270098A1
• Time in Patent Office: 2,316 Days
• Field of Search: 600480-505
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/02116 of pulse wave amplitude A61B5/02225 takes precedence
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/7271 Specific aspects of physiological measurement analysis A61B5/316, A61B5/349 and A61B5/374 take precedence

Abstract

The application relates to an apparatus and a method for estimating a central systolic blood pressure (cSBP) of a subject, in which a peripheral blood pressure waveform of the subject'"'"'s pulse and at least two peripheral blood pressure measurements within the cardiac cycle of the subject are determined and the peripheral blood pressure waveform is manipulated with a transfer function to provide an estimate of the central blood pressure waveform of the subject'"'"'s pulse. The at least two peripheral blood pressure measurements within the cardiac cycle of the subject and the peripheral blood pressure waveform of the subject'"'"'s pulse are determined at substantially the same point on a peripheral artery of the subject. The estimate of the central blood pressure waveform of the subject'"'"'s pulse provides an estimate of the central systolic blood pressure of the subject.

Claims

1. A method of estimating a central systolic blood pressure (cSBP) comprising:

obtaining a peripheral blood pressure waveform of a pulse of a human subject within at least one cardiac cycle of the human subject, wherein the peripheral blood pressure waveform of the human subject'"'"'s pulse is determined on a brachial artery of the human subject using a blood pressure cuff, and wherein the peripheral blood pressure waveform is obtained when pressure in the blood pressure cuff is adjusted to a defined pressure;

applying a transfer function to the peripheral blood pressure waveform and calibrating the peripheral blood pressure waveform using defined peripheral blood pressure measurements, wherein the defined peripheral blood pressure measurements comprise at least two of pSBP, pDBP and pMAP, to provide an estimate of the central blood pressure waveform of the human subject'"'"'s pulse; and

electronically estimating the cSBP of the human subject using the estimate of the central blood pressure waveform.

2. The method of claim 1, wherein the obtaining the peripheral blood pressure waveform of the subject'"'"'s pulse comprises:

recording a plurality of peripheral blood pressure waveforms corresponding to a plurality of cardiac cycles; and

averaging the waveforms to obtain a single average peripheral blood pressure waveform,

wherein the applying the transfer function is carried out using the average peripheral blood pressure waveform.

8. The method of claim 1, wherein the obtaining, applying and estimating are carried out using at least one processor in communication with the blood pressure cuff.

3. An apparatus for estimating a central systolic blood pressure (cSBP) of a human subject, the apparatus comprising:

a non-invasive blood pressure determining device configured to obtain a peripheral blood pressure waveform of a pulse of the human subject within at least one cardiac cycle of the subject, wherein the non-invasive blood pressure determining device comprises a brachial blood pressure cuff that is adjusted to have a defined pressure to obtain the peripheral blood pressure waveform; and

a processor to (i) calibrate the peripheral blood pressure waveform using defined peripheral blood pressure measurements, wherein the defined peripheral blood pressure measurements comprise at least two of pSBP, pDBP and pMAP and (ii) apply a transfer function to the peripheral blood pressure waveform to provide an estimate of the central blood pressure waveform of the human subject'"'"'s pulse, and

wherein the estimate of the central blood pressure waveform of the human subject'"'"'s pulse provides an estimate of the central systolic blood pressure (cSBP) of the human subject.

4. The apparatus of claim 3, wherein a plurality of peripheral blood pressure waveforms are obtained and averaged to give an average peripheral blood pressure waveform, and wherein the processor applies the transfer function to the average peripheral blood pressure waveform.

5. The apparatus of claim 3, wherein the transfer function is or comprises a filter or an algorithm to remove amplification associated with transmission of the subject'"'"'s pulse from a heart of the subject to a peripheral artery.

6. The apparatus of claim 3, wherein the transfer function comprises a Butterworth 1^st order filter.

7. A device for use with a blood pressure cuff for estimating a central systolic blood pressure of a human subject, the device comprising:

a processor configured to apply a transfer function to a peripheral blood pressure waveform of the human subject'"'"'s pulse and use at least two defined peripheral blood pressure measurements comprising at least two of pSBP, pDBP and pMAP to calibrate the peripheral blood pressure waveform to provide an estimate of a central waveform of the human subject'"'"'s pulse,

wherein the processor is in communication with a blood pressure cuff which determines the peripheral blood pressure waveform of a respective human subjects pulse on a brachial artery, and wherein the processor is configured to calculate an estimate of central systolic blood pressure of a respective human subject using a corresponding estimate of the central waveform.