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Lung function analysis method and apparatus

  • US 9,289,156 B2
  • Filed: 10/27/2010
  • Issued: 03/22/2016
  • Est. Priority Date: 11/03/2009
  • Status: Active Grant
First Claim
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1. A computer-implemented method for assessing a subject'"'"'s lung, the method comprising:

  • receiving, at a processor, first data which has been obtained from the subject by performing Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI);

    determining, from the first data, a first time-varying input of a partial pressure of oxygen measured in tissue water;

    determining, from the first data, a second time varying input of a partial pressure of oxygen content in inhaled gases;

    determining, from the first data, a third time varying input of oxygen content in venous blood;

    generating, by the processor, an output by fitting a model of lung function to said first time varying input, said second time varying input, and said third time varying input,wherein the model of lung function comprises a first model component and a second model component, the first model component having a first input corresponding to said first time varying input of a partial pressure of oxygen measured in tissue water and a second input corresponding to said second time varying input of oxygen content in inhaled gases and modelling a transfer of gaseous oxygen from a gaseous space within the lung to a biological material within the lung, the second model component having an input corresponding to said third time varying input of oxygen content in venous blood and modelling a transfer of oxygen from the lungs by an oxygenation of the venous blood to create oxygenated blood; and

    determining a measure of ventilation and perfusion within the subject'"'"'s lung based upon said generated output.

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