Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
First Claim
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1. A method for treating damaged cardiac tissue using sub-atmospheric pressure, comprising:
- i. placing a porous material proximate the damaged cardiac tissue to provide gaseous communication between one or more pores of the porous material and the damaged cardiac tissue, the porous material comprising at least one of an electrospun material, a cast material, an open-cell foam, and a printed material;
ii. sealing the porous material in situ over the damaged cardiac tissue to provide a region about the damaged cardiac tissue for maintaining sub-atmospheric pressure at the damaged cardiac tissue, and locating a bio-incorporable cover over the damaged cardiac tissue and sealing the bio-incorporable cover to cardiac tissue proximate the damaged cardiac tissue;
iii. operably connecting a vacuum source in gaseous communication with the porous material for producing sub-atmospheric pressure at the damaged cardiac tissue; and
iv. activating the vacuum source to provide sub-atmospheric pressure at the damaged cardiac tissue.
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Abstract
A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
491 Citations
49 Claims
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1. A method for treating damaged cardiac tissue using sub-atmospheric pressure, comprising:
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i. placing a porous material proximate the damaged cardiac tissue to provide gaseous communication between one or more pores of the porous material and the damaged cardiac tissue, the porous material comprising at least one of an electrospun material, a cast material, an open-cell foam, and a printed material; ii. sealing the porous material in situ over the damaged cardiac tissue to provide a region about the damaged cardiac tissue for maintaining sub-atmospheric pressure at the damaged cardiac tissue, and locating a bio-incorporable cover over the damaged cardiac tissue and sealing the bio-incorporable cover to cardiac tissue proximate the damaged cardiac tissue; iii. operably connecting a vacuum source in gaseous communication with the porous material for producing sub-atmospheric pressure at the damaged cardiac tissue; and iv. activating the vacuum source to provide sub-atmospheric pressure at the damaged cardiac tissue. - View Dependent Claims (2, 3, 4, 5, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49)
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6. A method for treating damaged cardiac tissue using sub-atmospheric pressure, comprising:
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i. placing a porous bio-incorporable material proximate the damaged cardiac tissue to provide gaseous communication between one or more pores of the porous material and the damaged cardiac tissue; ii. sealing the porous material in situ over the damaged cardiac tissue to provide a region about the damaged cardiac tissue for maintaining sub-atmospheric pressure at the damaged cardiac tissue, and locating a bio-incorporable cover over the damaged cardiac tissue and sealing the bio-incorporable cover to cardiac tissue proximate the damaged cardiac tissue; iii. operably connecting a vacuum source in gaseous communication with the porous material for producing sub-atmospheric pressure at the damaged cardiac tissue; and iv. activating the vacuum source to provide sub-atmospheric pressure at the damaged cardiac tissue. - View Dependent Claims (7)
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Specification