Intranasal naloxone compositions and methods of making and using same
First Claim
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1. A method of treating a known or suspected opioid overdose comprising the step of intranasally administering a composition comprising from about 5 mg/mL to about 50 mg/mL of an opioid antagonist naloxone;
- from about 5 mM to about 50 mM citric acid;
from about 2 to about 20 mM disodium ethylene diamine tetraacetic acid (EDTA);
from about 0.1 to about 2 weight % benzyl alcohol; and
a carrier to an individual in need thereof,wherein said composition is administered via the nasal membranes to said individual;
wherein said individual is administered a dose, per naris, of from about 0.1 to about 2 mg.
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Abstract
Disclosed herein are compositions containing an opioid antagonist such as naloxone and one or more pharmaceutically acceptable excipients. The compositions may be used for intranasal delivery of Naloxone for the treatment of, for example, opioid overdose in an individual in need thereof. Also disclosed are methods of making compositions containing Naloxone, and devices for nasal delivery of naloxone compositions.
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Citations
10 Claims
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1. A method of treating a known or suspected opioid overdose comprising the step of intranasally administering a composition comprising from about 5 mg/mL to about 50 mg/mL of an opioid antagonist naloxone;
- from about 5 mM to about 50 mM citric acid;
from about 2 to about 20 mM disodium ethylene diamine tetraacetic acid (EDTA);
from about 0.1 to about 2 weight % benzyl alcohol; and
a carrier to an individual in need thereof,wherein said composition is administered via the nasal membranes to said individual; wherein said individual is administered a dose, per naris, of from about 0.1 to about 2 mg. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- from about 5 mM to about 50 mM citric acid;
Specification