Carriers for improved drug delivery
First Claim
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1. A carrier-drug conjugate, comprising a targeting group comprising vitamin D that is not hydroxylated at the Carbon 1 position stably linked to a therapeutic peptide.
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Reexamination
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Abstract
The invention provides carriers that enhance the absorption, half-life or bioavailability of therapeutic compounds. The carriers comprise targeting groups that bind the Vitamin D Binding protein (DBP), conjugation groups for coupling the targeting groups to the therapeutic compounds, and optionally scaffolding moieties.
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Citations
25 Claims
- 1. A carrier-drug conjugate, comprising a targeting group comprising vitamin D that is not hydroxylated at the Carbon 1 position stably linked to a therapeutic peptide.
- 4. A pharmaceutical composition comprising a carrier-drug conjugate comprising a targeting group that is vitamin D that is not hydroxylated at the Carbon 1 position linked to a therapeutic peptide via a scaffold that is between 300 Da and 60,000 Da.
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20. A pharmaceutical composition comprising:
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(a) a therapeutic peptide (b) a stably attached scaffold, (c) a targeting group that is Vitamin D that is not hydroxylated at the Carbon 1 position, wherein after administration to a first subject, said therapeutic peptide has a half life measured by a functional assay of blood samples taken at a plurality of time points that is greater than a half life of said therapeutic peptide administered to a second subject without said attached scaffold and targeting group as measured by said functional assay of blood samples taken at said plurality of time points. - View Dependent Claims (21, 22, 23)
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- 24. A carrier-drug conjugate comprising a targeting group that is non-hormonal vitamin D stably linked to a therapeutic peptide.
Specification