Medical device rapid drug releasing coatings comprising oils, fatty acids and/or lipids
First Claim
1. A medical device for delivering a therapeutic agent to a tissue, the medical device comprising a coating layer overlying an exterior surface of the medical device, the coating layer consisting essentially of:
- a hydrophobic therapeutic agent chosen from paclitaxel, rapamycin, doxorubicin, beta-lapachone, vitamin D2, vitamin D3, and combinations thereof;
at least one water-soluble first additive selected from the group consisting of PEG fatty esters, gluconolactone, and combinations thereof; and
at least one water-insoluble second additive selected from the group consisting of phosphatidylcholine, phosphatidylethanolamine, dimyristoylphosphatidylcholine, and combinations thereof.
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Abstract
The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. In further embodiments, the chemical compound is water-soluble.
475 Citations
17 Claims
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1. A medical device for delivering a therapeutic agent to a tissue, the medical device comprising a coating layer overlying an exterior surface of the medical device, the coating layer consisting essentially of:
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a hydrophobic therapeutic agent chosen from paclitaxel, rapamycin, doxorubicin, beta-lapachone, vitamin D2, vitamin D3, and combinations thereof; at least one water-soluble first additive selected from the group consisting of PEG fatty esters, gluconolactone, and combinations thereof; and at least one water-insoluble second additive selected from the group consisting of phosphatidylcholine, phosphatidylethanolamine, dimyristoylphosphatidylcholine, and combinations thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A medical device for delivering a therapeutic agent to a tissue, the medical device comprising a coating layer overlying an exterior surface of the medical device, the coating layer consisting essentially of:
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a hydrophobic therapeutic agent chosen from paclitaxel, rapamycin, doxorubicin, lapachone, vitamin D2, vitamin D3, and combinations thereof; at least one water-soluble first additive selected from the group consisting of PEG fatty esters, gluconolactone, and combinations thereof; and at least one water-insoluble second additive selected from the group consisting of soybean oil, vegetable oil, flower oil, coconut oil, palm oil, olive oil, fish oil, butanoic acid, hexanoic acid, octanoic acid, decanoic acid, dodecanoic acid, tetradecanoic acid, hexadecanoic acid, octadecanoic acid, octadecatrienoic acid, eicosanoic acid, eicosenoic acid, eicosatetraenoic acid, eicosapentaenoic acid, docosahexaenoic acid, tocotrienol, butyric acid, caproic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, vaccenic acid, linoleic acid, alpha-linolenic acid, gamma-linolenic acid, behenic acid, erucic acid, lignoceric acid, and combinations thereof. - View Dependent Claims (15, 16, 17)
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Specification