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Drug releasing coatings for medical devices

  • US 9,289,539 B2
  • Filed: 04/10/2015
  • Issued: 03/22/2016
  • Est. Priority Date: 11/20/2006
  • Status: Active Grant
First Claim
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1. A medical device for delivering a therapeutic agent to a tissue, the medical device comprising:

  • a coating layer overlying an exterior surface of the medical device, wherein;

    the coating layer consisting essentially of a therapeutic agent and at least one additive;

    the therapeutic agent is a water-insoluble drug chosen from paclitaxel, rapamycin, daunorubicin, doxorubicin, beta-lapachone, biologically active vitamin D, and combinations thereof;

    the at least one additive is selected from the group consisting of urea, acetamide, lactic acid amide, aminoacid amide, acetaminophen, uric acid, polyurea, urethane, urea derivatives, niacinamide, N-methylacetamide, N,N-dimethylacetamide, sulfacetamide sodium, versetamide, lauric diethanolamide, lauric myristic diethanolamide, N,N-Bis(2-hydroxyethyl stearamide), cocamide EA, and cocamide DEA.

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