Remotely controlled drug delivery systems
First Claim
Patent Images
1. A drug delivery device comprising:
- a reservoir adapted to contain at least one deliverable; and
a release mechanism sealingly engaged with the reservoir to selectively release the at least one deliverable upon application of an external stimulus, wherein the release mechanism is a diaphragm membrane further comprising a polymeric matrix which is substantially non-porous to the at least one deliverable in a first state, and porous to the at least one deliverable in a second state achieved in response to the external stimulus, wherein the polymeric matrix comprises a plurality of suspended magnetic particles, which upon application of a magnetic field causes displacement of the diaphragm to the second state.
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Abstract
Drug delivery devices responsive to at least one external stimulus are described, along with methods for their preparation and use. The devices can be configured to respond to the stimulus, providing “on demand” release of one or more deliverables such as pharmaceutical drugs.
40 Citations
19 Claims
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1. A drug delivery device comprising:
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a reservoir adapted to contain at least one deliverable; and a release mechanism sealingly engaged with the reservoir to selectively release the at least one deliverable upon application of an external stimulus, wherein the release mechanism is a diaphragm membrane further comprising a polymeric matrix which is substantially non-porous to the at least one deliverable in a first state, and porous to the at least one deliverable in a second state achieved in response to the external stimulus, wherein the polymeric matrix comprises a plurality of suspended magnetic particles, which upon application of a magnetic field causes displacement of the diaphragm to the second state. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for local release of a deliverable, the method comprising:
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positioning a drug delivery device at a site in need of receiving the deliverable, wherein the drug delivery device comprises; a reservoir adapted to contain at least one deliverable; and a release mechanism sealingly engaged with the reservoir to selectively release the at least one deliverable upon application of an external stimulus, wherein the release mechanism is a diaphragm membrane further comprising a polymeric matrix which is substantially non-porous to the at least one deliverable in a first state, and porous to the at least one deliverable in a second state achieved in response to the external stimulus, wherein the polymeric matrix comprises a plurality of suspended magnetic particles, which upon application of a magnetic field causes displacement of the diaphragm to the second state; and applying an external stimulus at or near the drug delivery device to release the deliverable. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A kit comprising:
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a drug delivery device comprising; a reservoir adapted to contain at least one deliverable; and a release mechanism sealingly engaged with the reservoir to selectively release the at least one deliverable upon application of an external stimulus, wherein the release mechanism is a diaphragm membrane further comprising a polymeric matrix which is substantially non-porous to the at least one deliverable in a first state, and porous to the at least one deliverable in a second state achieved in response to the external stimulus, wherein the polymeric matrix comprises a plurality of suspended magnetic particles, which upon application of a magnetic field causes displacement of the diaphragm to the second state; and a magnetic field generator. - View Dependent Claims (19)
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Specification