Movement disorder therapy system, devices and methods, and methods of remotely tuning
First Claim
1. A method of tuning a movement disorder therapy system comprising steps of:
- providing a movement disorder diagnostic device to a subject with an implanted deep brain stimulation (DBS) device operable according to adjustable DBS parameters,wherein the movement disorder diagnostic device comprises at least one physiological or movement sensor capable of generating a signal, and the DBS parameters include one or more of electrode polarity, frequency, amplitude, current, pulse width/wavelength, waveform type, and contact configuration;
instructing, via a device with a processor in communication with the movement disorder diagnostic device, or by the clinician, physician or technician, the subject to perform at least one movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy,wherein the movement disorder test corresponds to a set of first level DBS parameters of the DBS therapy;
measuring, by the movement disorder diagnostic device, symptomatic movement of the subject to obtain movement data based at least in part on the generated signal from the at least one physiological or movement sensor during the at least one movement disorder test;
transmitting, by the movement disorder diagnostic device, the measured movement data to the device with a processor;
extracting, by the device with a processor, at least one kinematic feature from the measured movement data;
processing, by the device with a processor, the at least one kinematic feature with an algorithm to obtain at least one score;
displaying, on a display, the subject'"'"'s measured movement data and the at least one score to a clinician, physician or technician;
determining, by the clinician, physician or technician, based at least in part on the subject'"'"'s measured movement data and the at least one score, a set of second level DBS parameters to alter the subject'"'"'s performance on the at least one movement disorder test;
entering, automatically by the device with a processor or manually by the clinician, physician or technician, the second level DBS parameters into a programmer device in communication with the subject'"'"'s DBS device such that the subject'"'"'s DBS device operates under the second level DBS parameters; and
supplying, by the DBS device, a stimulation current to the subject'"'"'s brain under the second level DBS parameters to provide altered DBS therapy to the subject.
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Accused Products
Abstract
The present invention relates to methods for remotely tuning treatment parameters in movement disorder therapy systems where the subject and clinician are located remotely from each other. The present invention still further provides methods of quantifying movement disorders for the treatment of patients who exhibit symptoms of such movement disorders including, but not limited to, Parkinson'"'"'s disease and Parkinsonism, Dystonia, Chorea, and Huntington'"'"'s disease, Ataxia, Tremor and Essential Tremor, Tourette syndrome, stroke, and the like. The present invention yet further relates to methods of remotely tuning a therapy device using objective quantified movement disorder symptom data to determine the therapy setting or parameters to be transmitted and provided to the subject via his or her therapy device. The present invention also provides treatment and tuning remotely, allowing for home monitoring of subjects.
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Citations
16 Claims
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1. A method of tuning a movement disorder therapy system comprising steps of:
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providing a movement disorder diagnostic device to a subject with an implanted deep brain stimulation (DBS) device operable according to adjustable DBS parameters, wherein the movement disorder diagnostic device comprises at least one physiological or movement sensor capable of generating a signal, and the DBS parameters include one or more of electrode polarity, frequency, amplitude, current, pulse width/wavelength, waveform type, and contact configuration; instructing, via a device with a processor in communication with the movement disorder diagnostic device, or by the clinician, physician or technician, the subject to perform at least one movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy, wherein the movement disorder test corresponds to a set of first level DBS parameters of the DBS therapy; measuring, by the movement disorder diagnostic device, symptomatic movement of the subject to obtain movement data based at least in part on the generated signal from the at least one physiological or movement sensor during the at least one movement disorder test; transmitting, by the movement disorder diagnostic device, the measured movement data to the device with a processor; extracting, by the device with a processor, at least one kinematic feature from the measured movement data; processing, by the device with a processor, the at least one kinematic feature with an algorithm to obtain at least one score; displaying, on a display, the subject'"'"'s measured movement data and the at least one score to a clinician, physician or technician; determining, by the clinician, physician or technician, based at least in part on the subject'"'"'s measured movement data and the at least one score, a set of second level DBS parameters to alter the subject'"'"'s performance on the at least one movement disorder test; entering, automatically by the device with a processor or manually by the clinician, physician or technician, the second level DBS parameters into a programmer device in communication with the subject'"'"'s DBS device such that the subject'"'"'s DBS device operates under the second level DBS parameters; and supplying, by the DBS device, a stimulation current to the subject'"'"'s brain under the second level DBS parameters to provide altered DBS therapy to the subject. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of tuning a movement disorder therapy system comprising steps of:
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providing a movement disorder diagnostic device to a subject with an implanted deep brain stimulation (DBS) device operable according to adjustable DBS parameters, wherein the movement disorder diagnostic device comprises at least one physiological or movement sensor capable of generating a signal, and the DBS parameters include one or more of electrode polarity, frequency, amplitude, current, pulse width/wavelength, waveform type, and contact configuration; instructing, via a device with a processor in communication with the movement disorder diagnostic device, or by the clinician, physician or technician, the subject to perform at least one movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy, wherein the movement disorder test corresponds to a set of first level DBS parameters of the DBS therapy; measuring, by the movement disorder diagnostic device, symptomatic movement of the subject to obtain movement data based at least in part on the generated signal from the at least one physiological or movement sensor during the at least one movement disorder test; transmitting, by the movement disorder diagnostic device, the measured movement data to the device with a processor; extracting, by the device with a processor, at least one kinematic feature from the measured movement data; processing, by the device with a processor, the at least one kinematic feature with an algorithm to obtain at least one score; displaying, on a display, the subject'"'"'s measured movement data and the at least one score to a clinician, physician or technician; determining, by the clinician, physician or technician, based at least in part on the subject'"'"'s measured movement data and the at least one score, at least two optional groups of DBS parameters to alter the subject'"'"'s performance on the at least one movement disorder test, each optional group of DBS parameters corresponding to a different desired outcome or constraint; selecting, by the clinician, physician or technician, one of the at least two optional groups of DBS parameters; entering, automatically by the device with a processor or manually by the clinician, physician or technician, the selected optional group of DBS parameters into a programmer device in communication with the subject'"'"'s DBS device such that the subject'"'"'s DBS device operates under the selected optional group of DBS parameters; and supplying, by the DBS device, a stimulation current to the subject'"'"'s brain under the selected optional group of DBS parameters to provide altered DBS therapy to the subject. - View Dependent Claims (8, 9, 10, 11)
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12. A method of tuning a movement disorder therapy system comprising steps of:
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providing a movement disorder diagnostic device to a subject with an implanted deep brain stimulation (DBS) device operable according to adjustable DBS parameters, wherein the movement disorder diagnostic device comprises at least one physiological or movement sensor capable of generating a signal, and the DBS parameters include one or more of electrode polarity, frequency, amplitude, current, pulse width/wavelength, waveform type, and contact configuration; instructing, via a device with a processor in communication with the movement disorder diagnostic device, or by the clinician, physician or technician, the subject to perform at least one movement disorder test while the subject is undergoing DBS therapy or is under the effects of DBS therapy, wherein the movement disorder test corresponds to a set of first level DBS parameters of the DBS therapy; measuring, by the movement disorder diagnostic device, symptomatic movement of the subject to obtain movement data based at least in part on the generated signal from the at least one physiological or movement sensor during the at least one movement disorder test; transmitting, by the movement disorder diagnostic device, the measured movement data to the device with a processor; extracting, by the device with a processor, at least one kinematic feature from the measured movement data; processing, by the device with a processor, the at least one kinematic feature with an algorithm to obtain at least one score; displaying, on a display, the subject'"'"'s measured movement data and the at least one score to a clinician, physician or technician; determining, by the clinician, physician or technician, based at least in part on the subject'"'"'s measured movement data and the at least one score, a set of second level DBS parameters to alter the subject'"'"'s performance on the at least one movement disorder test; automatically entering, by the device with a processor, the second level DBS parameters into a programmer device in communication with the subject'"'"'s DBS device such that the subject'"'"'s DBS device operates under the second level DBS parameters; and supplying, by the DBS device, a stimulation current to the subject'"'"'s brain under the second level of DBS parameters to provide altered DBS therapy to the subject. - View Dependent Claims (13, 14, 15, 16)
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Specification