System for electroporation therapy
First Claim
1. An electroporation therapy system, comprising:
- a device having proximal and distal ends;
an electrode assembly comprising a plurality of electrically isolated electrode elements disposed at said distal end of said device;
a detector coupled to said elements configured to identify which elements have a conduction characteristic indicative of contact with tissue; and
an electroporation generator configured to energize said identified electrode elements in accordance with an electroporation energization strategy, wherein said plurality of electrode elements are arranged in at least a first array disposed on an outer surface of a tubular base wherein said tubular base comprises electrically-insulating material, said array extending along a first path having a shape substantially matching that of said base, an electroporation generator being configured to selectively energize said identified electrode elements of said first array in a bipolar fashion so as to produce a lesion in said tissue having said shape, and wherein said plurality of electrodes are further arranged in a second array disposed on said outer surface of said tubular base, said second array being offset from said first array by a predetermined distance and extending along a second path having said shape, said electroporation generator being further configured to selectively energize said identified electrode elements of said first and second array in a bipolar fashion therebetween so as to produce a lesion in said tissue having said shape and width corresponding to said predetermined distance.
1 Assignment
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Accused Products
Abstract
Catheter systems include direction-sensitive, multi-polar tip electrode assemblies for electroporation-mediated therapy, electroporation-induced primary necrosis therapy and electric field-induced apoptosis therapy, including configurations for producing narrow, linear lesions as well as distributed, wide area lesions. A monitoring system for electroporation therapy includes a mechanism for delivering electrochromic dyes to a tissue site as well as a fiber optic arrangement to optically monitor the progress of the therapy as well as to confirm success post-therapy. A fiber optic temperature sensing electrode catheter includes a tip electrode having a cavity whose inner surface is impregnated or coated with thermochromic/thermotropic material that changes color with changes in temperature. An optic fiber/detector arrangement monitors the thermochromic or thermotropic materials, acquiring a light signal and generating an output signal indicative of the spectrum of the light signal. An analyzer determines an electrode temperature based on the detector output and predetermined spectrum versus temperature calibration data.
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Citations
21 Claims
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1. An electroporation therapy system, comprising:
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a device having proximal and distal ends; an electrode assembly comprising a plurality of electrically isolated electrode elements disposed at said distal end of said device; a detector coupled to said elements configured to identify which elements have a conduction characteristic indicative of contact with tissue; and an electroporation generator configured to energize said identified electrode elements in accordance with an electroporation energization strategy, wherein said plurality of electrode elements are arranged in at least a first array disposed on an outer surface of a tubular base wherein said tubular base comprises electrically-insulating material, said array extending along a first path having a shape substantially matching that of said base, an electroporation generator being configured to selectively energize said identified electrode elements of said first array in a bipolar fashion so as to produce a lesion in said tissue having said shape, and wherein said plurality of electrodes are further arranged in a second array disposed on said outer surface of said tubular base, said second array being offset from said first array by a predetermined distance and extending along a second path having said shape, said electroporation generator being further configured to selectively energize said identified electrode elements of said first and second array in a bipolar fashion therebetween so as to produce a lesion in said tissue having said shape and width corresponding to said predetermined distance. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification