Fractionalized stimulation pulses in an implantable stimulator device

• US 9,289,610 B2
• Filed: 08/27/2012
• Issued: 03/22/2016
• Est. Priority Date: 05/15/2008
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Parramon, Jordi, Carbunaru, Rafael, Haller, Matt I.
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US13/595,746
• Publication Number:
  US 20130013025A1
• Time in Patent Office: 1,303 Days
• Field of Search: 607/70
• US Class Current: 1/1
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36125 Details of circuitry or electric components
• CPC Class Codes: A61N 1/36171 Frequency
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters
• CPC Class Codes: A61N 1/37235 Aspects of the external programmer

Abstract

A method for configuring stimulation pulses in an implantable stimulator device having a plurality of electrodes is disclosed, which method is particularly useful in adjusting the electrodes by current steering during initialization of the device. In one aspect, a set of ideal pulses for patient therapy is determined, in which at least two of the ideal pulses are of the same polarity and are intended to be simultaneous applied to corresponding electrodes on the implantable stimulator device during an initial duration. These pulses are reconstructed into fractionalized pulses, each comprised of pulse portions. The fractionalized pulses are applied to the corresponding electrodes on the device during a final duration, but the pulse portions of the fractionalized pulses are not simultaneously applied during the final duration.

Claims

1. An implantable stimulator device (ISD) configured to provide stimulation between at least a first electrode and a second electrode, comprising:

logic configured to define a group of a plurality of constant current pulses in a single timing channel, wherein the pulses are either only anodic or only cathodic, and wherein the pulses within the group have a second frequency greater than or equal to 2000 Hz; and

source or sink circuitry configured to periodically apply the group of the pulses to the first electrode at a first frequency, wherein the second electrode comprises the other of an anode or cathode compared to the pulses in the group.

2. The device of claim 1, wherein the pulses within the group have a duty cycle.

3. The device of claim 2, wherein the duty cycle is approximately 50%.

4. The device of claim 1, wherein the second frequency is less than or equal to 10000 Hz.

5. The device of claim 1, further comprising a receiver configured to wirelessly receive the first frequency from a device external to the ISD.

6. The device of claim 5, wherein the first frequency is determined to be therapeutically effective for a patient at the external device.

7. The device of claim 1, wherein the group of the pulses has a first duration.

8. The device of claim 7, further comprising a receiver configured to wirelessly receive the first duration from a device external to the ISD.

9. The device of claim 1, further comprising a lead, wherein the first and second electrodes are carried by the lead.

10. The device of claim 1, further comprising a first lead and a second lead, wherein the first electrode is carried by the first lead, and wherein the second electrode is carried by the second lead.

11. The device of claim 1, wherein the logic is further configured to define a time between consecutive applications of the group during which the pulses are not applied to the first electrode.

12. A method for providing stimulation between at least a first electrode and a second electrode of an implantable stimulator device (ISD), comprising:

constructing in the ISD a group of a plurality of constant current pulses that are either only anodic or only cathodic, wherein a second frequency of the pulses within the group is greater than or equal to 2000 Hz; and

periodically applying the group of the pulses to the first electrode of the ISD at a first frequency, wherein the periodically-applied group of the pulses is constructed in a single timing channel, and wherein the second electrode comprises the other of an anode or cathode compared to the pulses in the group.

13. The method of claim 12, wherein the pulses within each group have a duty cycle.

14. The method of claim 13, wherein the duty cycle is approximately 50%.

15. The method of claim 12, wherein the second frequency is less than or equal to 10000 Hz.

16. The method of claim 12, wherein the ISD is coupled to a lead, and wherein the first and second electrodes are carried by the lead.

17. The method of claim 12, wherein the ISD is coupled to first and second leads, wherein the first electrode is carried by the first lead, and wherein the second electrode is carried by the second lead.

18. The method of claim 12, wherein the method occurs when the ISD is implanted in a patient.

19. The method of claim 18, wherein the ISD is coupled to first and second leads implanted in the patient, and wherein the first and second electrodes are carried on one or both of the first and second leads.

20. The method of claim 19, wherein the first and second leads are respectively positioned to the right and left of a physiological midline of the patient'"'"'s spinal cord.

21. The method of claim 19, wherein the first and second leads are positioned within an epidural space of the patient'"'"'s spinal cord.

22. The method of claim 18, further comprising determining that the first frequency is therapeutically effective for the patient.

23. The method of claim 12, wherein the second electrode is not pulsed when the group of the pulses is periodically applied.

24. The method of claim 12, wherein the group of the pulses is periodically applied to the first electrode of the ISD via current source or sink circuitry coupled to the first electrode.

25. The method of claim 12, wherein the second electrode comprises the other of an anode or cathode by virtue of current source or sink circuitry coupled to the second electrode.

26. The method of claim 12, wherein current source circuitry is coupled to the anodic one of the first and second electrodes, and wherein current sink circuitry is coupled to the cathodic one of the first and second electrodes.

27. The method of claim 12, wherein the group of the pulses is periodically applied to the first electrode with a time between consecutive applications of the group during which the pulses are not applied.

28. An implantable stimulator device (ISD) configured to provide stimulation between at least a first electrode and a second electrode, comprising:

logic configured to define;

a group of a plurality of constant current pulses that are either only anodic or only cathodic, wherein the pulses within the group have a second frequency greater than or equal to 2000 Hz; and

a time between consecutive applications of the group during which the pulses are not applied to the first electrode, wherein the time establishes a first frequency at which the group of the pulses is to be periodically applied to the first electrode; and

source or sink circuitry configured to periodically apply the group of the pulses to the first electrode at the first frequency, wherein the second electrode comprises the other of an anode or cathode compared to the pulses in the group.

29. The device of claim 28, wherein the pulses within the group have a duty cycle.

30. The device of claim 29, wherein the duty cycle is approximately 50%.

31. The device of claim 28, wherein the second frequency is less than or equal to 10000 Hz.

32. The device of claim 28, wherein the group of the pulses has a first duration.

33. The device of claim 32, further comprising a receiver configured to wirelessly receive the first duration from a device external to the ISD.

34. The device of claim 28, further comprising a lead, wherein the first and second electrodes are carried by the lead.

35. The device of claim 28, further comprising a first lead and a second lead, wherein the first electrode is carried by the first lead, and wherein the second electrode is carried by the second lead.

36. A method for providing stimulation between at least a first electrode and a second electrode of an implantable stimulator device (ISD), comprising:

constructing in the ISD a group of a plurality of constant current pulses that are either only anodic or only cathodic, wherein a second frequency of the pulses within the group is greater than or equal to 2000 Hz; and

periodically applying the group of the pulses to the first electrode of the ISD at a first frequency, wherein the second electrode comprises the other of an anode or cathode compared to the pulses in the group,

wherein current source circuitry is coupled to the anodic one of the first and second electrodes, and wherein current sink circuitry is coupled to the cathodic one of the first and second electrodes.

37. The method of claim 36, wherein the pulses within each group have a duty cycle.

38. The method of claim 37, wherein the duty cycle is approximately 50%.

39. The method of claim 36, wherein the second frequency is less than or equal to 10000 Hz.

40. The method of claim 36, wherein the ISD is coupled to a lead, and wherein the first and second electrodes are carried by the lead.

41. The method of claim 36, wherein the ISD is coupled to first and second leads, wherein the first electrode is carried by the first lead, and wherein the second electrode is carried by the second lead.

42. The method of claim 36, wherein the method occurs when the ISD is implanted in a patient.

43. The method of claim 42, wherein the ISD is coupled to first and second leads implanted in the patient, and wherein the first and second electrodes are carried on one or both of the first and second leads.

44. The method of claim 43, wherein the first and second leads are respectively positioned to the right and left of a physiological midline of the patient'"'"'s spinal cord.

45. The method of claim 43, wherein the first and second leads are positioned within an epidural space of the patient'"'"'s spinal cord.

46. The method of claim 42, further comprising determining that the first frequency is therapeutically effective for the patient.

47. The method of claim 36, wherein the second electrode is not pulsed when the group of the pulses is periodically applied.

48. The method of claim 36, wherein the group of the pulses is periodically applied to the first electrode with a time between consecutive applications of the group during which the pulses are not applied.

49. A method for providing stimulation between at least a first electrode and a second electrode of an implantable stimulator device (ISD), comprising:

constructing in the ISD a group of a plurality of constant current pulses that are either only anodic or only cathodic, wherein a second frequency of the pulses within the group is greater than or equal to 2000 Hz; and

periodically applying the group of the pulses to the first electrode of the ISD at a first frequency, wherein the group of the pulses is periodically applied to the first electrode with a time between consecutive applications of the group during which the pulses are not applied, and wherein the second electrode comprises the other of an anode or cathode compared to the pulses in the group.

50. The method of claim 49, wherein the pulses within each group have a duty cycle.

51. The method of claim 50, wherein the duty cycle is approximately 50%.

52. The method of claim 49, wherein the second frequency is less than or equal to 10000 Hz.

53. The method of claim 49, wherein the ISD is coupled to a lead, and wherein the first and second electrodes are carried by the lead.

54. The method of claim 49, wherein the ISD is coupled to first and second leads, wherein the first electrode is carried by the first lead, and wherein the second electrode is carried by the second lead.

55. The method of claim 49, wherein the method occurs when the ISD is implanted in a patient.

56. The method of claim 55, wherein the ISD is coupled to first and second leads implanted in the patient, and wherein the first and second electrodes are carried on one or both of the first and second leads.

57. The method of claim 56, wherein the first and second leads are respectively positioned to the right and left of a physiological midline of the patient'"'"'s spinal cord.

58. The method of claim 56, wherein the first and second leads are positioned within an epidural space of the patient'"'"'s spinal cord.

59. The method of claim 55, further comprising determining that the first frequency is therapeutically effective for the patient.

60. The method of claim 49, wherein the second electrode is not pulsed when the group of the pulses is periodically applied.

61. The method of claim 49, wherein the group of the pulses is periodically applied to the first electrode of the ISD via current source or sink circuitry coupled to the first electrode.

62. The method of claim 49, wherein the second electrode comprises the other of an anode or cathode by virtue of current source or sink circuitry coupled to the second electrode.