System and method for estimating and manipulating estimated radiation dose
First Claim
1. A method for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the method comprising:
- (a) determining a dose modification voxel for which it is desired to modify the dose value and determining a corresponding magnitude of desired dose modification;
(b) receiving the achievable dose distribution estimate, the dose modification voxel and the corresponding magnitude of desired dose modification as input to a processor;
(c) for each of a plurality of beams;
(i) characterizing, using the processor, each beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and
(ii) identifying, using the processor, one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel;
(d) modifying, using the processor, the intensity values of the one or more identified dose-change beamlets based on the magnitude of desired dose modification, wherein modifying the intensity values of the one or more identified dose-change beamlets comprises, for each of the one or more identified dose-change beamlets, modifying the intensity value of each identified dose-change beamlet by a corresponding amount, the corresponding amount based on the magnitude of the desired dose modification;
(e) updating, using the processor, the achievable dose distribution estimate to account for the modified intensity values of the identified dose-change beamlets; and
(f) outputting, from the processor, the updated achievable dose distribution estimate.
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Abstract
Methods are provided for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject. One such method comprises: determining a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams: (i) characterizing the beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing the projection of the beamlet into space; and (ii) identifying one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modifying the intensity values of at least one of the dose-change beamlets; and updating the achievable dose distribution estimate to account for the modified intensity values of the at least one of the dose-change beamlets.
20 Citations
49 Claims
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1. A method for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the method comprising:
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(a) determining a dose modification voxel for which it is desired to modify the dose value and determining a corresponding magnitude of desired dose modification; (b) receiving the achievable dose distribution estimate, the dose modification voxel and the corresponding magnitude of desired dose modification as input to a processor; (c) for each of a plurality of beams; (i) characterizing, using the processor, each beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and (ii) identifying, using the processor, one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; (d) modifying, using the processor, the intensity values of the one or more identified dose-change beamlets based on the magnitude of desired dose modification, wherein modifying the intensity values of the one or more identified dose-change beamlets comprises, for each of the one or more identified dose-change beamlets, modifying the intensity value of each identified dose-change beamlet by a corresponding amount, the corresponding amount based on the magnitude of the desired dose modification; (e) updating, using the processor, the achievable dose distribution estimate to account for the modified intensity values of the identified dose-change beamlets; and (f) outputting, from the processor, the updated achievable dose distribution estimate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A method for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the method comprising:
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(a) determining a dose modification voxel for which it is desired to modify the dose value and determining a corresponding magnitude of desired dose modification; (b) receiving the achievable dose distribution estimate, the dose modification voxel and the corresponding magnitude of desired dose modification as input to a processor; (c) for each of a plurality of beams; (i) characterizing, using the processor, each beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and (ii) identifying, using the processor, one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; (d) modifying, using the processor, the intensity values of the one or more identified dose-change beamlets based on the magnitude of desired dose modification, wherein modifying the intensity values of the one or more identified dose-change beamlets comprises, for each of the one or more identified dose-change beamlets, modifying the intensity value of each identified dose-change beamlet by a corresponding amount, the corresponding amount based on the magnitude of the desired dose modification; and (e) updating, using the processor, the achievable dose distribution estimate to account for the modified intensity values of the one or more identified dose-change beamlets and, after updating, using the processor, the achievable dose distribution estimate, determining, using the processor, one or more radiation delivery parameters based on the updated achievable dose estimate, the one or more radiation delivery parameters suitable for use by the radiation delivery apparatus for treatment of the subject; (f) outputting, from the processor, the updated achievable dose distribution estimate and the one or more radiation delivery parameters; wherein determining, using the processor, one or more radiation delivery parameters based on the updated achievable dose estimate comprises performing an iterative optimization process; wherein performing the iterative optimization process comprises estimating an optimized dose distribution over a three-dimensional range of voxels resulting from an optimization beam having a spatially varying two-dimensional optimization intensity distribution characterized by a two-dimensional array of optimization beamlets wherein each optimization beamlet is associated with a corresponding optimization intensity value, the estimating comprising; associating an optimization ray line with each optimization beamlet, the optimization ray line representing a projection of the optimization beamlet into space; convolving the two-dimensional optimization intensity distribution with a two-dimensional optimization dose estimate kernel to obtain a two-dimensional optimization convolved intensity distribution, the two-dimensional optimization convolved intensity distribution comprising an optimization convolved intensity value for each optimization beamlet; and for each optimization beamlet in the two-dimensional array of optimization beamlets;
identifying voxels in the three- dimensional range of voxels that are intersected by the optimization ray line associated with the optimization beamlet; and
adding an optimization dose contribution to the intersected voxels, the added optimization dose contribution based on the optimization convolved intensity value of the optimization beamlet.
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43. A system for permitting manipulation of an achievable dose distribution estimate deliverable by a radiation delivery apparatus for proposed treatment of a subject, the achievable dose distribution estimate defined over a three-dimensional range of voxels with a dose value for each voxel, the system comprising a computer-based controller connectable to control a radiation delivery apparatus, the controller configured to:
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determine a dose modification voxel for which it is desired to modify the dose value and a corresponding magnitude of desired dose modification; for each of a plurality of beams; characterize each beam as a two-dimensional array of beamlets, wherein each beamlet is associated with a corresponding intensity value and a ray line representing a projection of the beamlet into space; and identify one or more dose-change beamlets which have associated ray lines that intersect the dose modification voxel; modify the intensity values of the one or more identified dose-change beamlets based on the magnitude of the desired dose modification, wherein the controller is configured to modify the intensity values of the one or more identified dose change beamlets by, for each of the one or more identified dose-change beamlets, modifying the intensity value of each identified dose-change beamlet by a corresponding amount, the corresponding amount based on the magnitude of the desired dose modification; update the achievable dose distribution estimate to account for the modified intensity values of the identified dose-change beamlets. - View Dependent Claims (44, 45, 46, 47, 48, 49)
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Specification