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Methods of making hollow microneedle arrays and articles and uses therefrom

  • US 9,289,925 B2
  • Filed: 03/22/2010
  • Issued: 03/22/2016
  • Est. Priority Date: 04/10/2009
  • Status: Active Grant
First Claim
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1. A method of manufacturing a hollow microneedle array comprising:

  • (a) providing a first mold half comprising a stacked laminate mold, the stacked laminate mold comprising a plurality of plates and a plurality of cavities, wherein each of the plates comprises;

    (i) opposed first and second major surfaces; and

    (ii) a first mold surface connecting said first and second major surfaces; and

    wherein the plurality of cavities is open at least to the first mold surface and includes a cavity surface wherein the cavity surface intersects each respective plate'"'"'s first major surface and each respective plate'"'"'s first mold surface;

    (b) providing a second mold half comprising a second mold surface, wherein the second mold surface comprises a plurality of projections;

    (c) contacting at least the first mold surface or the second mold surface with polymeric material; and

    (d) inserting the plurality of projections into the plurality of cavities.

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