Tissue engineered blood vessel
First Claim
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1. A method of making a tissue engineered blood vessel comprising the steps of:
- a. Providing a scaffold comprising a solution of poly(p-dioxanone) and 1,1,1,3,3,3-hexafluoro-2-propanol solvent formed as an electrospun tubular scaffold of randomly oriented fibers;
b. Cutting the electrospun tubular scaffold to form a scaffold sheet;
c. Seeding said scaffold sheet with cells;
d. Rolling said seeded sheet into a tube; and
e. Culturing the tube in a bioreactor.
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Abstract
Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.
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Citations
1 Claim
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1. A method of making a tissue engineered blood vessel comprising the steps of:
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a. Providing a scaffold comprising a solution of poly(p-dioxanone) and 1,1,1,3,3,3-hexafluoro-2-propanol solvent formed as an electrospun tubular scaffold of randomly oriented fibers; b. Cutting the electrospun tubular scaffold to form a scaffold sheet; c. Seeding said scaffold sheet with cells; d. Rolling said seeded sheet into a tube; and e. Culturing the tube in a bioreactor.
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Specification