Integrated analytical system and method
First Claim
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1. A nucleic acid sequencing instrument comprising:
- a removable sequencing chip having at least 10,000 analytical devices, each analytical device having a reaction cell, optical elements, and detection elements that detect light emitted from the reaction cell and convert the detected light into electrical data signals, wherein the reaction cell, the optical elements and the detection elements are pre-aligned and locked in during manufacturing of the removable sequencing chip and there is no substantial open or free space between the reaction cell, optical elements, and detection elements;
the sequencing chip comprising integrated waveguides that deliver illumination light to the reaction cells;
the sequencing chip having electrical connections that transfer the electrical data signals from the sequencing chip;
a fluidic sample delivery device that delivers reagents for sequencing a sample on the sequencing chip;
an illumination source that provides illumination to the integrated waveguides on the sequencing chip;
a camera board in contact with the electrical connections on the sequencing chip, the camera board comprising circuitry for processing electrical data signals from the sequencing chip; and
a computer in electrical communication with the camera board that receives processed data from the camera board.
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Abstract
An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.
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Citations
18 Claims
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1. A nucleic acid sequencing instrument comprising:
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a removable sequencing chip having at least 10,000 analytical devices, each analytical device having a reaction cell, optical elements, and detection elements that detect light emitted from the reaction cell and convert the detected light into electrical data signals, wherein the reaction cell, the optical elements and the detection elements are pre-aligned and locked in during manufacturing of the removable sequencing chip and there is no substantial open or free space between the reaction cell, optical elements, and detection elements;
the sequencing chip comprising integrated waveguides that deliver illumination light to the reaction cells;
the sequencing chip having electrical connections that transfer the electrical data signals from the sequencing chip;a fluidic sample delivery device that delivers reagents for sequencing a sample on the sequencing chip; an illumination source that provides illumination to the integrated waveguides on the sequencing chip; a camera board in contact with the electrical connections on the sequencing chip, the camera board comprising circuitry for processing electrical data signals from the sequencing chip; and a computer in electrical communication with the camera board that receives processed data from the camera board. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification