Method and system for a non-invasive measurement of optically active component concentration

• US 9,295,419 B2
• Filed: 05/06/2013
• Issued: 03/29/2016
• Est. Priority Date: 05/06/2013
• Status: Active Grant

• Current Assignee: T.G.M. Technologies Ltd.
• Original Assignee: T.G.M. Technologies Ltd.
• Inventors: Weiss, Aryeh Uri, Oren, Nataly, Koren, Eitan
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US13/887,417
• Publication Number:
  US 20140330097A1
• Time in Patent Office: 1,058 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14558 by polarisation
• CPC Class Codes: A61B 5/6816 Ear lobe
• CPC Class Codes: A61B 5/6819 Nose
• CPC Class Codes: A61B 5/682 Mouth, e.g., oral cavity; tongue; Lips; Teeth
• CPC Class Codes: A61B 5/6825 Hand
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424

Abstract

It is disclosed a device for measuring a concentration of glucose, for example, in a translucent piece of a body, like an earlobe, a tissue connecting two fingers, a nasal ala, or a cheek. The piece is illuminated by a linearly polarized laser beam at a certain polarization direction. Consequently, a diffused radiated light is emitted from the piece, including a directed beam. The device includes a polarizing beam splitter which receives the directed beam, a lens, a sensor array, and means for connecting to a processor. The splitter splits components of the directed beam at two mutually orthogonal linear polarization directions into two polarized beams propagating at two respective different directions. The lens images the distribution of the directed beam on the translucent piece on two spatially separated groups within the sensor arrays. The processor defines pixel pairs from a first and second images which correspond to a same point on the second surface of the translucent piece, and subtracts the first pixels from the respective second pixels to get a difference image. In addition, the processor calculates the variance of the difference image, and calculates the desired concentration accordingly.

Claims

1. A system for measuring a concentration of an optically active component in a translucent piece of material having a first and a second opposing surfaces, the device comprising:

(a) a polarizing beam splitter configured to receive a directed beam from the second surface and to split components of the received directed beam at two mutually orthogonal linear polarization directions into a first and a second polarized beams propagating at different directions such that said first polarized beam is directed to a first group of light sensors, and said second polarized beam is directed to a second group of light sensors;

(b) said first and second group of light sensors are two spatially separated groups of light sensors; and

(c) a processor connected to said first group of light sensors and said second group of light sensors, said processor configured for processing the sensed light at said two groups using mapping of light sensors in one of said two spatially separated groups to the light sensors in a second group thereof,

and said processor is configured for calculating the concentration of the optically active material using said mapping result of measured sensed light.

2. The system of claim 1 wherein the system includes a diode laser and a linear polarizer configured to be disposed between said diode laser and the first surface of said translucent piece of material.

3. The system of claim 1 wherein one or more lenses are disposed between the polarizing splitter and said one or more arrays of light sensors said one or more lenses being configured to image the distribution of the directed beam on the translucent piece on two spatially separated groups within the sensor.

4. The system of claim 1 wherein said light sensors are selected from the group of sensors consisting of:

(A) charge coupled device sensors; and

(B) complementary metal oxide semiconductor sensors.

5. The system of claim 1 wherein the system includes a Wollaston prism for polarized splitting.

6. The system of claim 1 wherein the system is configured to measure glucose concentration by light illumination of a tissue selected from a group of tissues consisting of an earlobe, a tissue connecting two fingers, a nasal ala, and a cheek.

7. The system of claim 1 wherein each of said two mutually orthogonal linear polarization directions has an angle between 40°

and 50°

relative to said certain polarization direction.

8. The system of claim 1 wherein the system further includes means for coupling the polarizing splitter to said translucent piece.

9. The system of claim 1 wherein said sensors are wirelessly connected to said processor.

10. The system of claim 1 wherein said mapping is made in accordance with a calculation of weighted centers of the two polarized beams.

11. The system of claim 1 wherein two sensor arrays detecting said two polarized beams have identical sensor layout used for said mapping.

12. A device for measuring a concentration of an optically active component in a translucent piece of material having a first and a second opposing surfaces, the first surface being illuminated by a linearly polarized monochromatic light beam at a certain polarization direction, a diffused radiated light being emitted from the second surface, the diffused radiated light including a relatively directed beam used by the device for measuring the concentration of the optically active component, the device comprising:

(a) a polarizing beam splitter configured to receive the directed beam from the second surface and to split components of the received beam at two mutually orthogonal linear polarization directions into first and a second polarized beams propagating at two respective different directions such that said first polarized beam is directed to a first group of light sensors, and said second polarized beam is directed to a second group of light sensors;

(b) one or more lenses disposed between the polarizing splitter and said light sensors, such as to image the distribution of said directed beam on the second surface of said translucent piece on two spatially separated groups within said light sensors; and

(c) a processor configured for using the light sensed by said two spatially separated groups for determining the concentration of the optically active component in said translucent piece of material, based on the image mapping to a same distribution of light on the second surface of said translucent piece of material.

13. The device of claim 12 wherein the processor is adapted for:

(i) defining pixel pairs having each a first pixel from a first image of the distribution of said directed beam on the second surface of said translucent piece, and a second pixel from a second image thereof, said first pixel and said second pixel corresponding substantially to a same point on the second surface of said translucent piece; and

(ii) determining the concentration of said optically active component within said translucent piece based on the defined pixel pairs.

14. The device of claim 13 wherein said processor is further adapted for at least one calculating step of a group of calculating steps consisting of:

(iii) subtracting the first pixels from the respective second pixels to get a difference image;

(iv) adding the first pixels to the respective second pixels to get a sum image;

(v) for non-zero sum image pixels, calculating pixel contrast values each equaling a ratio of a difference image pixel and a sum image pixel; and

(vi) calculating a statistical parameter characterizing the variance of the light sensed by said sensor.

15. The device of claim 12 wherein the polarizing splitter is a Wollaston prism.

16. The device of claim 12 wherein the device measures glucose concentration by light illumination of a tissue selected from a group of tissues consisting of an earlobe, a tissue connecting two fingers, a nasal ala, and a cheek.

17. The device of claim 12 wherein each of said two mutually orthogonal linear polarization directions have an angle between 40°

and 50°

relative to said certain polarization direction.

18. The device of claim 12 wherein the system further includes means for coupling the polarizing splitter to said translucent piece.

19. The device of claim 12 wherein said light sensors are wirelessly connected to said processor.

20. A method for measuring a concentration of an optically active component in a translucent piece of material having a first and a second opposing surfaces, the method comprising:

(a) illuminating the first surface by a linearly polarized monochromatic light beam at a certain polarization direction such that a diffused radiated light being emitted from the second surface, the diffused radiated light including a relatively directed beam;

(b) disposing a polarizing beam splitter between the second surface of said translucent piece and one or more arrays of light sensors, said polarizing beam splitter being configured to receive the directed beam and to split components of the received beam at two mutually orthogonal linear polarization directions to two polarized beams propagating at two respective different directions;

(c) disposing one or more lenses between the polarizing splitter and said one or more arrays of light sensors, such as to image the distribution of said directed beam on the second surface of said translucent piece on two spatially separated groups within said one or more arrays of light sensors; and

(d) determining the concentration of the optically active component in said translucent piece of material by mapping images of the light sensed by said two spatially separated groups to a same distribution of light on the second surface and calculating the concentration using said mapping result.