Minimizing intestinal dysfunction

• US 9,295,715 B2
• Filed: 10/03/2011
• Issued: 03/29/2016
• Est. Priority Date: 10/02/2010
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Delano, Frank A., Schmid-Schonbein, Geert W., Saltzman, Darin
• Primary Examiner(s): Skowronek, Karlheinz R
• Assistant Examiner(s): Lee, Li
• Application Number:
  US13/876,943
• Publication Number:
  US 20140018293A1
• Time in Patent Office: 1,639 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/195 having an amino group
• CPC Class Codes: A61K 31/415 1,2-Diazoles
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61K 31/4965 Non-condensed pyrazines
• CPC Class Codes: A61K 31/497 containing further heterocyclic rings
• CPC Class Codes: A61K 38/38 Albumins
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/00 Drugs for disorders of the alimentary tract or the digestive system
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/04 Antibacterial agents

Abstract

Techniques are disclosed for treating or reducing symptoms associated with abdominal dysfunction or ileus following surgery or other abdominal episode by treating the area with a combination of one or more protease, antibacterial compound, and inflammatory lipid mediator.

Claims

1. A method for treating ileus, the method comprising:

administering into the lumen of an intestine of an individual a first therapeutic dose comprising a protease inhibitor; and

administering to an abdominal cavity of the individual a second therapeutic dose comprising a combination of the same protease inhibitor used in the first therapeutic dose and an antibacterial compound.

2. The method of claim 1, wherein the protease inhibitor is effective for inhibiting the function of one or more of the following:

serine protease, plasma protease, MMP, amylase and lipase.

3. The method of claim 2, wherein the protease inhibitor is cyclokapron.

4. The method of claim 3, wherein the dose of cyclokapron is 10 to 50 mg/100 ml.

5. The method of claim 1, wherein the antibacterial compound is effective against gram-positive and gram-negative bacteria.

6. The method of claim 5, wherein the antibacterial compound includes one or more of ciprofloxacin, metronidazole, imipenem and cilastatin, ticarcillin and clavulanate, cefuroxime, doxycycline.

7. The method of claim 1, wherein the first and second therapeutic doses are administered prophylactically.

8. The method of claim 1, wherein the second therapeutic dose further comprises an inflammatory lipid mediator binding protein.

9. The method of claim 8, wherein the inflammatory lipid mediator binding protein is albumin.

10. The method of claim 9, wherein the dose of inflammatory lipid mediator binding protein is 10 to 50 mg/100 ml.

11. A method for treating abdominal dysfunction, the method comprising:

administering into the lumen of an intestine of an individual a first therapeutic dose comprising a protease inhibitor; and

administering to an abdominal cavity of the individual a second therapeutic dose comprising a combination of the same protease inhibitor used in the first therapeutic dose and an antibacterial compound.

12. The method of claim 11, wherein the protease inhibitor is effective for inhibiting the function of one or more of the following:

serine protease, plasma protease, MMP, amylase and lipase.

13. The method of claim 12, wherein the protease inhibitor is cyclokapron.

14. The method of claim 13, wherein the dose of cyclokapron is 10 to 50 mg/100 ml.

15. The method of claim 11, wherein the antibacterial compound is effective against gram-positive and gram-negative bacteria.

16. The method of claim 15, wherein the antibacterial compound includes one or more of ciprofloxacin, metronidazole, imipenem and cilastatin, ticarcillin and clavulanate, cefuroxime, doxycycline.

17. The method of claim 11, wherein the first and second therapeutic doses are administered prophylactically.

18. The method of claim 11, wherein the second therapeutic dose further comprises an inflammatory lipid mediator binding protein.

19. The method of claim 18, wherein the inflammatory lipid mediator binding protein is albumin.

20. The method of claim 19, wherein the dose of inflammatory lipid mediator binding protein is 10 to 50 mg/100 ml.