Indolizino[3,2-c]quinoline derivatives, pharmaceutically acceptable salt thereof, preparation method thereof and pharmaceutical composition for treatment of cystic fibrosis containing the same as active ingredient
First Claim
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1. An indolizino[3,2-c]quinoline derivative represented by the following Chemical Formula 1 or pharmaceutically acceptable salt thereof:
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Abstract
Provided are an indolizino[3,2-c]quinoline derivative, pharmaceutically acceptable salt thereof, and a method for preparing the same. The indolizino[3,2-c]quinoline derivative, pharmaceutically acceptable salt thereof may function as an agonist of cystic fibrosis conductance transmembrane regulator, and thus may be useful for an agent for preventing or treating diseases caused by degradation of activity of cystic fibrosis conductance transmembrane regulator and for a pharmaceutical composition for stimulating proliferation of stem cells.
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15 Claims
- 1. An indolizino[3,2-c]quinoline derivative represented by the following Chemical Formula 1 or pharmaceutically acceptable salt thereof:
- 6. A method for preparing an indolizino[3,2-c]quinoline derivative represented by the following Chemical Formula 1 by reacting a compound represented by the following Chemical Formula 2 with an aldehyde in the presence of a catalyst:
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11. An agonist of cystic fibrosis conductance transmembrane regulator (CFTR), comprising the indolizino[3,2-c]quinoline derivative represented by the following Chemical Formula 1 or pharmaceutically acceptable salt thereof as an active ingredient:
- 12. A pharmaceutical composition for treating diseases caused by degradation of activity of cystic fibrosis conductance transmembrane regulator, comprising the indolizino[3,2-c]quinoline derivative represented by the following Chemical Formula 1 or pharmaceutically acceptable salt thereof as an active ingredient:
- 14. A pharmaceutical composition for stimulating stem cell proliferation, comprising the indolizino[3,2-c]quinoline derivative represented by the following Chemical Formula 1 or pharmaceutically acceptable salt thereof as an active ingredient:
Specification