Albumin fusion proteins
First Claim
1. A method of treating a Type I diabetes in a patient, comprising the step of administering a therapeutically effective amount of a pharmaceutical composition comprising an albumin fusion protein consisting of two tandemly oriented GLP-1(7-36(A8G)) polypeptides and SEQ ID NO:
- 1038, wherein the C-terminus of said two tandemly oriented GLP-1(7-36(A8G)) polypeptides is fused to the N-terminus of SEQ ID NO;
1038.
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Accused Products
Abstract
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
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Citations
8 Claims
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1. A method of treating a Type I diabetes in a patient, comprising the step of administering a therapeutically effective amount of a pharmaceutical composition comprising an albumin fusion protein consisting of two tandemly oriented GLP-1(7-36(A8G)) polypeptides and SEQ ID NO:
- 1038, wherein the C-terminus of said two tandemly oriented GLP-1(7-36(A8G)) polypeptides is fused to the N-terminus of SEQ ID NO;
1038. - View Dependent Claims (4, 5, 6, 7)
- 1038, wherein the C-terminus of said two tandemly oriented GLP-1(7-36(A8G)) polypeptides is fused to the N-terminus of SEQ ID NO;
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2. A method of treating a patient with a disease or disorder that is modulated by GLP-1, or fragment or variant thereof, comprising the step of administering a therapeutically effective amount of a pharmaceutical composition comprising an albumin fusion protein consisting of two tandemly oriented GLP-1(7-36(A8G)) polypeptides and SEQ ID NO:
- 1038, wherein the C-terminus of said two tandemly oriented GLP-1(7-36(A8G)) polypeptides is fused to the N-terminus of SEQ ID NO;
1038 wherein said disease or disorder comprises Type 1 diabetes. - View Dependent Claims (3)
- 1038, wherein the C-terminus of said two tandemly oriented GLP-1(7-36(A8G)) polypeptides is fused to the N-terminus of SEQ ID NO;
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8. A method of treating a human comprising administering to said human a pharmaceutical composition comprising an albumin fusion protein produced by a host cell comprising construct ID 3070, which is contained in ATCC deposit No. PTA-4671, and wherein said human has Type 1 diabetes.
Specification