Apparatus and method for non-invasive measurement of cardiac output

• US 9,297,874 B2
• Filed: 03/12/2014
• Issued: 03/29/2016
• Est. Priority Date: 05/01/2003
• Status: Active Grant

• Current Assignee: Aspect Imaging Ltd.
• Original Assignee: Aspect Imaging Ltd.
• Inventors: Rapoport, Uri
• Primary Examiner(s): CHAO, ELMER M
• Application Number:
  US14/206,050
• Publication Number:
  US 20140194731A1
• Time in Patent Office: 748 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: G01R 33/36 Electrical details, e.g. matching or coupling of the coil to the receiver
• CPC Class Codes: G01R 33/383 using permanent magnets
• CPC Class Codes: G01R 33/3873 using ferromagnetic bodies ; Passive shimming
• CPC Class Codes: G01R 33/48 NMR imaging systems
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]

Abstract

A comparatively light and compact permanent magnet arrangement for an MRI apparatus has a pair of opposed permanent magnet arrays with a shimming system to adjust the uniformity and strength of a magnetic field in a central chamber of the apparatus. The MRI apparatus is used to examine the extremities of a patient to determine cardiovascular characteristics from an analysis of the blood flow through selected arteries in the extremity. The information collected can be used to calculate such characteristics as total cardiac output, blood flow, arterial wall thickness and elasticity and the presence of plaque.

Claims

1. A method for non-invasively measuring cardiac output of a patient, the method comprising the steps of:

providing a magnetic resonance imaging (MRI) unit of a size which is significantly smaller than the size of a full-body MRI unit, said MRI unit comprises a pair of opposed magnet assemblies generating a magnetic field across an air gap there between, said air gap is dimensioned to receive a human arm;

placing said MRI unit at a height suitable to receive an arm of a human subject in a sitting or a supine position, and positioning said patient in a sitting or in a supine position respectively;

placing an arm of said patient in said air gap;

providing an array of RF coils around said patient'"'"'s arm, said array of RF coils is configured to pulse and detect electromagnetic signals;

pulsing said RF coils and detecting signals produced thereby at selected time intervals over one or more heartbeat cycles of said patient;

collecting data regarding the radial and the ulnar arteries in said patient'"'"'s arm;

analyzing said data to determine the flow rate of blood through said radial and ulnar arteries at said selected time intervals;

creating cross-sectional view images of said radial and ulnar arteries and determining cross-sectional areas of the radial and ulnar arteries at said selected time intervals;

calculating the volume of blood flowing through the radial and ulnar arteries per heartbeat or per time unit; and

calculating the total cardiac output of said patient by using known values of the percentage of cardiac output passing through the radial and ulnar arteries.

2. The method of claim 1, wherein said MRI unit is placed on a desk and wherein said patient is seated at said desk.

3. The method of claim 1, wherein said MRI unit comprises one or more shim magnets adapted to increase the strength and uniformity of the magnetic field across said air gap, each of said shim magnets is provided with at least one adjusting bolt rotatably journaled thereto, and wherein said method further comprises a step of rotating one or more of said adjusting bolts to increase the strength and uniformity of said magnetic field.

4. The method of claim 1, wherein said MRI unit weights about 250 Kg and wherein said unit has a cross-section of about 60 cm by 60 cm.

5. The method of claim 1, wherein said array of RF coils comprises a plurality of coils positioned equidistantly about a perimeter of said array.

6. The method according to claim 5, wherein pulsing said RF coils comprises pulsing the coils sequentially at selected points about said perimeter to optimize imaging.

7. The method according to claim 5, herein said method comprises rotating said array of RF coils about said patient'"'"'s arm to optimize imaging.

8. The method according to claim 5, wherein said plurality of RF coils are disposed within a sleeve adapted to be slipped over said patient'"'"'s arm.

9. The method according to claim 1, wherein pulsing said RF coils is timed to commence with the heartbeat of said patient.

10. The method of claim 1, further comprising a step of measuring wall thickness of the radial and ulnar arteries in said patient'"'"'s arm.

11. The method of claim 1, further comprising a step of measuring elasticity of the radial and ulnar arteries in said patient'"'"'s arm.

12. The method of claim 1, further comprising a step of measuring flow mediated dilation of the radial and ulnar arteries in said patient'"'"'s arm.

13. The method as recited in claim 1, further comprising a step of detection of presence, type and thickness of plaque in the radial and ulnar arteries in said patient'"'"'s arm.