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Mice that produce antigen-binding proteins with pH-dependent binding characteristics

  • US 9,301,510 B2
  • Filed: 03/15/2013
  • Issued: 04/05/2016
  • Est. Priority Date: 03/16/2012
  • Status: Active Grant
First Claim
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1. A non-human animal comprising(i) in its germline genome a genetically modified immunoglobulin heavy chain locus comprising an unrearranged human immunoglobulin heavy chain variable region nucleotide sequence, wherein the unrearranged heavy chain variable region nucleotide sequence comprises an addition of at least one histidine codon or a substitution of at least one non-histidine codon with a histidine codon, wherein the histidine codon is not encoded by a corresponding human germline heavy chain variable region gene segment;

  • andwherein the added or substituted histidine codon is present in a complementary determining region 3 (CDR3) encoding sequence.

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