Systems and methods for exploiting pulmonary artery pressure obtained from an implantable sensor to detect cardiac rhythm irregularities

• US 9,301,702 B2
• Filed: 11/19/2012
• Issued: 04/05/2016
• Est. Priority Date: 11/19/2012
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Ngo, Thao, Kresge, Kathleen, Kane, Michael, Simon, Scott Patrick
• Primary Examiner(s): BERHANU, ETSUB D
• Application Number:
  US13/681,241
• Publication Number:
  US 20140142443A1
• Time in Patent Office: 1,233 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/02152 specially adapted for venous pressure
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/4836 Diagnosis combined with treatment in closed-loop systems or methods A61B5/0036 takes precedence
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium

Abstract

Techniques are provided for use with a pulmonary artery pressure (PAP) monitor having an implantable PAP sensor. In one example, a PAP signal is sensed that is representative of beat-by-beat variations in PAP occurring during individual cardiac cycles of the patient. The PAP monitor detects intervals within the signal corresponding to the durations of cardiac cycles, then detects cardiac rhythm irregularities based on the intervals. For example, the PAP monitor can detect and distinguish atrial fibrillation, ventricular fibrillation and ventricular tachycardia based on the stability of the intervals of the PAP signal along with other information such as ventricular rate. The PAP monitor can also detect and distinguish premature contractions based on durations of the intervals. Examples where the PAP monitor is a component of an implantable cardiac rhythm management device (CRMD) are also provided.

Claims

1. A method for use with an implantable pulmonary artery pressure sensor for implant within a patient, the method comprising:

sensing a pulmonary artery pressure (PAP) signal representative of variations in PAP occurring during cardiac cycles of the patient;

detecting intervals within the PAP signal corresponding to durations of the cardiac cycles;

detecting one or more cardiac rhythm irregularities, including premature contractions, based on the intervals within the PAP signal, and

delivering cardiac therapy to the patient in response to the detection of an irregularity.

2. The method of claim 1 wherein detecting intervals within the PAP signal includes:

detecting one or more fiducial points within the PAP signal; and

measuring one or more intervals between the fiducial points corresponding to durations of cardiac cycles.

3. The method of claim 2 wherein the fiducial points include one or more of a pulmonary artery systole (PAS) point, a pulmonary artery diastole (PAD) point and a dicrotic notch.

4. The method of claim 1 wherein detecting a cardiac rhythm irregularity based on the intervals within the PAP signal includes:

evaluating a stability of the intervals of the PAP signal; and

detecting the cardiac rhythm irregularity based on the stability of the intervals.

5. The method of claim 4 wherein evaluating the stability of the intervals within the PAP signal includes:

tracking PAP intervals over a plurality of cardiac cycles;

rejecting the longest and shortest intervals;

selecting the second longest and second shortest intervals; and

determining a difference between the second longest and second shortest intervals as a stability indicator.

6. The method of claim 4 wherein determining the stability of the intervals within the PAP signal includes:

calculating an average PAP waveform interval stability value; and

comparing the average PAP waveform interval stability value to a baseline PAP waveform interval stability to generate a stability indicator.

7. The method of claim 4 wherein detecting the cardiac rhythm irregularity based on the stability of the intervals of the PAP signal includes:

comparing the stability of the intervals of the PAP signal against a stability criteria indicative of irregular cardiac rhythm; and

generating an indication of irregular cardiac rhythm if the stability is found to be unstable relative to the stability criteria.

8. The method of claim 7 wherein the stability criteria is one or more of a programmed threshold value and a patient baseline threshold value.

9. The method of claim 7 wherein, if an irregular cardiac rhythm is indicated the method further comprises, discriminating the type of irregular cardiac rhythm by:

detecting a ventricular rate from the intervals;

comparing the ventricular rate against a tachycardia rate threshold indicative of tachycardia; and

generating an indication of atrial fibrillation (AF) with controlled ventricular response if the ventricular rate is below the tachycardia rate threshold.

10. The method of claim 9 wherein, if an irregular cardiac rhythm is indicated but the ventricular rate is not below the tachycardia rate threshold the method further comprises:

detecting a parameter representative of waveform morphology of the PAP signal;

comparing the parameter representative of the waveform morphology to a baseline morphology parameter associated with normal sinus rhythm to generate a morphology match indicator; and

detecting a peak within the PAP signal indicative of pulmonary artery systole (PAS) and assessing any significant reduction in PAS from a baseline peak amplitude;

wherein if the PAS peaks are relatively inconsistent and the morphology match indicator indicates a relatively poor morphology match, an indication of ventricular fibrillation (VF) is generated; and

if the PAS peaks are relatively consistent and the morphology match indicator indicates a relatively good morphology match, an indication of atrial fibrillation (AF) with rapid ventricular response is generated.

11. The method of claim 4 further including discriminating ventricular tachycardia (VT) from normal sinus rhythm in circumstances where the PAP signal intervals are relatively stable.

12. The method of claim 11 wherein discriminating VT from normal sinus rhythm in circumstances where the PAP signal intervals are relatively stable includes:

detecting a ventricular rate from the intervals;

comparing the ventricular rate against a tachycardia rate threshold indicative of tachycardia; and

generating an indication of VT if the rate exceeds the threshold and generating an indication of normal sinus rhythm otherwise.

13. The method of claim 1 wherein detecting premature contractions includes:

determining a duration of an interval within the PAP signal corresponding to an individual cardiac cycle;

comparing the duration against a premature contraction threshold; and

generating an indication of a premature contraction if the duration is below the premature contraction threshold.

14. The method of claim 13 further including discriminating premature atrial contractions (PACs) and premature ventricular contractions (PVCs) by:

detecting a parameter representative of waveform morphology of the PAP signal;

comparing the parameter representative of the waveform morphology to a baseline morphology parameter associated with normal sinus rhythm to generate a morphology match indicator; and

detecting a peak within the PAP signal indicative of pulmonary artery systole (PAS) and assessing any significant reduction in PAS peak amplitude from a baseline peak amplitude;

wherein if the PAS peaks are relatively inconsistent and the morphology match indicator indicates a relatively poor morphology match, the premature contraction is identified as a PVC; and

if the PAS peaks are relatively consistent and the morphology match indicator indicates a relatively good morphology match, the premature contraction is identified as a PAC.

15. The method of claim 14 further including, in response to detection of a PVC, recording diagnostics representative of one or more of:

the PAP signal, the PAS peak, the ventricular rate and any trends therein.

16. The method of claim 1 further including discriminating premature atrial contractions (PACs) and premature ventricular contractions (PVCs) by:

calculating a correlation coefficient associated with the PAP signal and signals representative of known PACs and known PVCs; and

discriminating PACs and PVCs based on the correlation coefficient.

17. The method of claim 16 wherein calculating the correlation coefficient associated with the PAP signal uses a kendall tau coefficient.

18. The method of claim 1 further including:

sensing a left atrial pressure (LAP) signal representative of variations in LAP during individual heart beats; and

detecting a cardiac rhythm irregularity based, in part, on the LAP signal.

19. The method of claim 18 further wherein detecting a cardiac rhythm irregularity based, in part , on the LAP signal includes one or more of:

morphology matching;

frequency spectrum analysis to distinguish atrial rhythms from ventricular rhythms; and

frequency spectrum analysis to evaluate a dominate frequency to discriminate high rate arrhythmias based on frequency.

20. The method of claim 1 wherein at least some of the steps are performed by an external system that receives PAP signals from the implantable PAP sensor.

21. The method of claim 1 wherein at least some of the steps are performed by an implantable cardiac rhythm management device that receives PAP signals from the implantable PAP sensor.

22. A system for use with an implantable pulmonary artery pressure sensor for implant within a patient, the system comprising:

a pulmonary artery pressure (PAP) signal input system operative to receive PAP signals from the PAP sensor wherein the PAP signal is representative of variations in PAP occurring during cardiac cycles of the patient;

a PAP interval detector operative to detect intervals within the PAP signal corresponding to durations of the cardiac cycles;

a PAP interval-based cardiac rhythm irregularity detector operative to detect a cardiac rhythm irregularity including premature contractions, based on the intervals within the PAP signal; and

a pulse generator coupled to the PAP interval-based cardiac rhythm irregularity detector, the pulse generator being adapted to deliver cardiac therapy to the patient in response to the detection of a rhythm irregularity.

23. The system of claim 22 wherein the system includes an implantable cardiac rhythm management device equipped to provide electrical cardiac stimulation to the heart of a patient when the device is implanted.

24. The system of claim 22 wherein the system includes an external PAP monitor operative to receive PAP signals from the implantable PAP sensor.

25. A system for use with an implantable pulmonary artery pressure sensor for implant within a patient, the system comprising:

means for sensing a pulmonary artery pressure (PAP) signal representative of variations in PAP occurring during cardiac cycles of the patient;

means for detecting intervals within the PAP signal corresponding to durations of the cardiac cycles;

means for detecting a cardiac rhythm irregularity, including premature contractions, based on the intervals within the PAP signal; and

means for delivering cardiac therapy to the patient in response to the detection of a cardiac rhythm irregularity.