Method for optimizing the gas conversion rate in a respiratory gas analyzer

• US 9,301,709 B2
• Filed: 09/27/2010
• Issued: 04/05/2016
• Est. Priority Date: 09/28/2009
• Status: Active Grant

• Current Assignee: Robert Bosch GmbH
• Original Assignee: Robert Bosch GmbH
• Inventors: Abraham-Fuchs, Klaus, Fleischer, Maximilian, Hiltawsky, Karsten, Hornung, Oliver, Krger-Sundhaus, Thomas, Magori, Erhard, Pohle, Roland, Von Sicard, Oliver
• Primary Examiner(s): Cheng, Jacqueline
• Assistant Examiner(s): TRAN, THO Q
• Application Number:
  US12/890,834
• Publication Number:
  US 20110077544A1
• Time in Patent Office: 2,017 Days
• Field of Search: 600/529, 600/532, 600/537, 600/543, 602/77, 423/235, 423/239.1
• US Class Current: 1/1
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence

Abstract

A method for optimizing a gas conversion rate in a respiratory gas analyzer, more particularly for nitric oxide (NO) in the respiratory gas, and an associated device are disclosed.

Claims

1. An improvement for a gas sensor device operable for measuring nitrogen monoxide in exhaled air, the device including a measurement chamber including an inlet for receiving a gas in communication with the measurement chamber and a gas sensor unit disposed within the chamber and including at least one gas sensor, comprising:

an arrangement for gas conversion in fluid communication between the inlet and the at least one gas sensor and configured to convert the nitrogen monoxide in the exhaled air to nitrogen dioxide measured by the gas sensor device, wherein the arrangement for gas conversion includes an effective cross section of greater than 0.01 cm² and less than 100 cm², and includes an effective volume of greater than 0.05 ml and less than 100 ml; and

means for determining a conversion rate of the arrangement for gas conversion and correcting the conversion rate in respect of a usage state of the arrangement for gas conversion.

2. The improvement as claimed in claim 1, wherein the arrangement for gas conversion includes an oxidizing agent.

3. The improvement as claimed in claim 1, wherein the arrangement for gas conversion includes a catalyst for catalyzing the oxidation of nitrogen monoxide to nitrogen dioxide.

4. The improvement as claimed in claim 1, wherein the arrangement for gas conversion is provided as a consumable.

5. The improvement as claimed in claim 1, wherein the arrangement for gas conversion is provided in a separate replaceable unit from the gas sensor unit.

6. The improvement as claimed in claim 1, wherein the arrangement for gas conversion includes a cylindrical design with a cross section of 0.5-2 cm² and a length of approximately 0.2-1 cm.

7. The improvement as claimed in claim 1, wherein the means for determining and correcting a conversion rate comprises:

means for determining the usage state of the arrangement for gas conversion and means for calculating the corrected conversion rate with the aid of the usage state.

8. The improvement as claimed in claim 7, wherein the means for determining the usage state of the arrangement for gas conversion comprises a flow sensor for determining a gas volume flowing through the arrangement for gas conversion, wherein the usage state is measured with the aid of the overall volume of gas that has flowed through the arrangement for gas conversion at any given time.

9. The device as claimed in claim 7, wherein the means for determining the usage state of the arrangement for gas conversion comprises means for counting the usage cycles of the device, wherein the usage state is measured with the aid of the overall number of usage cycles that the device has passed through at any given time.

10. The improvement as claimed in claim 7, wherein the means for calculating the corrected conversion rate has a computational arrangement for calculating the corrected conversion rate with the aid of the usage state, which computational arrangement is configured for calculating the corrected conversion rate as a function of the usage state or with the aid of stored or entered correction factors, wherein one correction factor of said correction factors to be used is correlated to the usage state.

11. The improvement as claimed in claim 10, wherein:

the arrangement for gas conversion includes a first and a second gas conversion arrangement with differing volumes V1 and V2, respectively, and

the means for determining and correcting the conversion rate additionally measures different concentrations c1 and c2 after conversion of identical initial concentrations of the gas analyte by each of said first and second gas conversion arrangements, respectively, wherein c2=q′

*c1 holds true, wherein q′

changes as a function of the usage state and can be used for calculating a corrected conversion rate with the aid of stored or entered correction factors or a function of q′

.

12. The improvement as claimed in claim 6, wherein the arrangement for gas conversion includes a cylindrical design with a cross section of 1 cm² and a length of 0.6 cm.

13. The improvement of claim 5, wherein:

the inlet for receiving a gas is defined in the measurement chamber;

an enclosed shaft is provided between the gas sensor unit and the inlet; and

the arrangement for gas conversion is configured to be replaceably mounted within the enclosed shaft in fluid communication between the inlet and the gas sensor unit.

14. The improvement of claim 13, wherein the enclosed shaft is incorporated within the measurement chamber.

15. The improvement of claim 1 in which the device includes an inlet, further comprising a valve between the inlet of the device and the arrangement for gas conversion.

16. The improvement of claim 1, wherein the arrangement for gas conversion is configured to display a color indicative of the usage state thereof.

17. The improvement of claim 1, further comprising a temperature sensor associated with the measurement chamber, and wherein said means for determining and correcting a conversion rate is further configured to correct the conversion rate as a function of the temperature measured in the chamber.

18. The improvement of claim 1, further comprising a device for heating the arrangement for gas conversion to a temperature at which the arrangement produces a maximum gas conversion rate.