Method for producing an analytical magazine

• US 9,301,715 B2
• Filed: 08/18/2011
• Issued: 04/05/2016
• Est. Priority Date: 02/19/2009
• Status: Active Grant

• Current Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Original Assignee: Roche Diabetes Care Inc. (Roche Holding AG)
• Inventors: List, Hans, Krmer, Uwe, Leichner, Wilhelm
• Primary Examiner(s): WRIGHT, PATRICIA KATHRYN
• Application Number:
  US13/212,715
• Publication Number:
  US 20120063970A1
• Time in Patent Office: 1,692 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 5/1411 by percutaneous method, e.g. by lancet
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150282 for piercing elements, e.g. blade, lancet, canula, needle
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150412 Pointed piercing elements, e.g. needles, lancets for piercing the skin blade-like piercing elements A61B5/150442
• CPC Class Codes: A61B 5/150503 Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/15146 Devices loaded with multiple lancets simultaneously, e.g. for serial firing without reloading, for example by use of stocking means. multiple simultaneous cutting or piercing A61B5/150977
• CPC Class Codes: A61B 5/15148 Constructional features of stocking means, e.g. strip, roll, disc, cartridge, belt or tube
• CPC Class Codes: A61B 5/15151 Each piercing element being stocked in a separate isolated compartment
• CPC Class Codes: A61B 5/15161 Characterized by propelling the piercing element in a radial direction relative to the disc
• CPC Class Codes: A61B 5/15176 Stocking means comprising cap, cover, sheath or protection for aseptic stocking
• CPC Class Codes: A61B 5/15186 Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/0609 Holders integrated in container to position an object
• CPC Class Codes: B01L 2300/0672 Integrated piercing tool
• CPC Class Codes: B01L 2300/0825 Test strips
• CPC Class Codes: B01L 2300/0838 Capillaries
• CPC Class Codes: B01L 2300/0861 Configuration of multiple channels and/or chambers in a single devices
• CPC Class Codes: B01L 2300/12 Specific details about materials
• CPC Class Codes: B01L 2300/16 Surface properties and coatings
• CPC Class Codes: B01L 3/502 : with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: B29C 65/16 : Laser beams
• CPC Class Codes: G01N 33/4875 : Details of handling test elements, e.g. dispensing or storage, not specific to a particular test method test-elements per se B01L, automatic analysers G01N35/00, in-vivo analysis on the human body for medical diagnosis A61B
• CPC Class Codes: Y10T 29/49817 : with other than ancillary treating or assembling
• CPC Class Codes: Y10T 29/49826 : Assembling or joining

Abstract

A method for producing an analytical magazine is proposed. The analytical magazine is designed to receive a plurality of analytical aids in a plurality of chambers. The method comprises the following steps: providing at least one first component of the analytical magazine, wherein the first component comprises a plurality of receptacles; providing a plurality of analytical aids, wherein the analytical aids are connected to one another and preferably oriented with respect to one another by at least one holding element; introducing the analytical aids into the receptacles; and separating the analytical aids from the holding element.

Claims

1. A method for producing an analytical magazine, wherein the analytical magazine is designed to receive a plurality of analytical aids in a plurality of chambers, wherein the method comprises the following steps:

providing first component of the analytical magazine, wherein the first component comprises a plurality of receptacles,

providing a plurality of analytical aids, each having a tip, wherein the analytical aids are connected to one another and oriented with respect to one another by at least one holding element, the analytical aids are arranged in a circular pattern such that the tips of the analytical aids point radially outward from a center of the circular pattern,

introducing the analytical aids into the receptacles, wherein all analytical aids are loaded into respective chambers simultaneously; and

separating the analytical aids from the holding element such that each of the analytical aids are individually positioned into respective receptacles and are separated from one another,

applying a second component of the analytical magazine onto the first component,

wherein the analytical aids are produced at least in part integrally with the holding element, wherein the analytical aids are worked from a common material of the holding element, wherein the common material is a metallic material, wherein the holding element extends between adjacent analytical aids and at least partially surrounds the tip of each of the adjacent analytical aids.

2. The method according to claim 1, wherein the holding element comprises a metal disk.

3. The method according to claim 1, wherein, prior to separating the analytical aids from the holding element, at least one connection to at least one desired breaking location is provided between the analytical aids and the holding element.

4. The method according to claim 1, wherein at least one of the chambers and the analytical aids are configured in such a way that the analytical aids are mounted such that they are movable for a sampling movement.

5. The method according to claim 1, wherein a process of applying the at least one test chemical is effected in such a way that in each case at least one region of the test chemical faces the interiors of the chambers and is accessible from inside the chambers.

6. An analytical magazine, made according to the method of claim 1, wherein the analytical magazine has at least one test chemical which is designed to change at least one measurable property in the presence of at least one analyte to be detected, wherein the at least one test chemical is applied to a continuous carrier and forms at least one test chemical field, wherein the test chemical field is an area coated with test chemical throughout and is provided jointly for the plurality of the chambers, wherein in each case at least one region of the test chemical field faces the interiors of the chambers and is accessible from inside the chambers.

7. The analytical magazine according to claim 6, wherein the test chemical field is part of a housing of the analytical magazine.

8. The analytical magazine according to claim 6, wherein the analytical aids furthermore have one lancet with at least one capillary channel for receiving body fluid, which is conducted to the test chemical field via the lancet.

9. The analytical magazine according to claim 8, wherein the capillary channel of the needle element is coated in order to enable improved transport of the body fluid.

10. An analytical magazine made according to the method of claim 1, wherein the analytical aids each comprise at least one test element with at least one test chemical for detecting at least one analyte in a liquid sample, wherein the test chemical is substantially stable with respect to ambient influences, wherein the first component and second component are connected to one another by a laser welding method, wherein at least one of the first component and the second component have a different transparency, wherein at least one of the first component and the second component is configured as a substantially rigid component.

11. The analytical magazine made according to the method of claim 1, wherein the first component and second component comprises a material selected from the following materials:

a polycarbonate;

an acrylonitrile-butadiene-styrene;

a cycloolefin copolymer;

a polymethyl methacrylate;

a polystyrene; and

a polyethylene terephthalate.

12. The method according to claim 1, wherein the analytical aids comprise at least one of lancets and micro-samplers.