Negative pressure wound closure device

• US 9,301,742 B2
• Filed: 12/23/2014
• Issued: 04/05/2016
• Est. Priority Date: 02/04/2011
• Status: Active Grant

• Current Assignee: University Of Massachusetts
• Original Assignee: University Of Massachusetts
• Inventors: Dunn, Raymond
• Primary Examiner(s): HAND, MELANIE JO
• Application Number:
  US14/581,685
• Publication Number:
  US 20150112290A1
• Time in Patent Office: 469 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/0057 Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect sutures A61B17/04; closing rectum or urethra near body surface A61F2/0009
• CPC Class Codes: A61B 17/08 Wound clamps or clips, i.e. not or only partly penetrating the tissue suture bridges A61B17/0466; Devices for bringing together the edges of a wound
• CPC Class Codes: A61B 2017/00561 creating a vacuum
• CPC Class Codes: A61B 2017/00654 entirely comprised between the two sides of the opening
• CPC Class Codes: A61B 2017/081 Tissue approximator A61B2017/1103, A61B17/8866 take precedence
• CPC Class Codes: A61F 13/05 specially adapted for use with sub-pressure or over-pressure therapy, wound drainage or wound irrigation, e.g. for use with negative-pressure wound therapy [NPWT]
• CPC Class Codes: A61F 2013/00174 possibility of applying pressure
• CPC Class Codes: A61F 2013/00536 for draining or irrigating wounds
• CPC Class Codes: A61F 2013/0054 for deep wounds
• CPC Class Codes: A61F 2013/00544 form or structure
• CPC Class Codes: A61F 2013/00548 net
• CPC Class Codes: A61M 1/84 Drainage tubes; Aspiration tips for negative pressure wound therapy A61M1/90; for surgical cutting instruments A61B17/32
• CPC Class Codes: A61M 1/90 Negative pressure wound therapy devices, i.e. devices for applying suction to a wound to promote healing, e.g. including a vacuum dressing
• CPC Class Codes: A61M 1/916 specially adapted for deep wounds

Abstract

The present invention relates to a negative pressure wound closure system and methods for using such a system. Preferred embodiments of the invention facilitate closure of the wound by preferentially contracting to provide for movement of the tissue. Preferred embodiments can utilize tissue grasping elements to apply a wound closing force to the tissue.

Claims

1. A method of closing a wound, comprising:

inserting a wound closure device within a wound opening, the wound closure device having a plurality of outward-projecting tissue anchors that engage with tissue at a margin of the wound, the wound closure device comprising a collapsible filler material having a stabilizing structure to enable collapse in a first direction and inhibit collapse in at least one second direction; and

applying a negative pressure to the wound closure device to collapse the filler material and displace the tissue at the wound margin to facilitate closure of the wound.

2. The method of claim 1, wherein the wound comprises an abdominal wound.

3. The method of claim 1, wherein the wound comprises a fasciotomy wound.

4. The method of claim 1, wherein the wound comprises a mediastinum wound.

5. The method of claim 1, further comprising:

removing fluid from the wound using a fluid management component.

6. The method of claim 5, wherein the fluid management component underlies the wound closure device, and the filler material collapses without interference from the fluid management component.

7. The method of claim 1, further comprising:

activating a negative pressure source coupled to the wound closure device to apply the negative pressure.

8. The method of claim 1, wherein the filler material comprises a porous material.

9. The method of claim 8, wherein the filler material comprises a foam.

10. The method of claim 1, wherein the tissue anchors are integrally formed in the filler material.

11. The method of claim 1, further comprising:

securing a film over a surface of the filler material, the tissue anchors projecting outward from the film.

12. The method of claim 11, wherein the film comprises a mesh material.

13. The method of claim 12, wherein securing the film comprises attaching the film to the filler using a plurality of inward facing anchors.

14. The method of claim 1, wherein the stabilizing structure comprises one or more regions of relatively rigid material surrounded by regions of relatively compressible material.

15. The method of claim 14, wherein the filler material has length, width and height dimensions, and the stabilizing structure inhibits collapse in the height dimension.

16. The method of claim 1, further comprising collapsing the filler material in at least one first direction to reapproximate the wound.

17. The method of claim 1, further comprising restricting the collapse of the filler material to a plane defined by the wound margins.

18. The method of claim 1, wherein the stabilizing structure comprises an endoskeleton made from comparatively rigid material.

19. The method of claim 18, wherein the endoskeleton comprises a plurality of spaced-apart rigid members forming a cross-hatched configuration.

20. The method of claim 18, further comprising collapsing the filler material a width dimension and elongating the filler material in the length dimension.

21. The method of claim 18, further comprising inhibiting collapse of the filler material in the height dimension with a plurality of rigid members extending in a height dimension.

22. The method of claim 21, wherein at least a portion of the rigid members extending in the height dimension extend around the periphery of the filler material.

23. The method of claim 18, wherein the endoskeleton comprises a network of interconnected rigid members that can articulate with respect to one another during collapse of the filler material.

24. The method of claim 18, wherein the tissue anchors are integrally formed in the endoskeleton.

25. The method of claim 18, further comprising inhibiting tilting motion of the filler material with truss members.

26. The method of claim 1, wherein the filler material has a smooth bottom surface.

27. The method of claim 26, further comprising removing fluid from the wound through micropores formed in the smooth bottom surface.

28. The method of claim 27, further comprising directing a distribution of vacuum force by varying at least one of the size and pore density of the micropores.

29. The method of claim 1, further comprising directing a distribution of vacuum force by varying at least one of a pore size and a pore density within the filler material.

30. The method of claim 1, further comprising removing portions of the filler material to adjust the size of the wound closure device.

31. The method of claim 30, further comprising removing portions of the filler material along pre-determined cleavage lines.

32. The method of claim 30, further comprising exposing embedded tissue anchors by removing portions of the filler material.

33. The method of claim 1, further comprising varying a force profile of the tissue anchors based on the type of tissue with which the anchors engage.

34. The method of claim 33, wherein the types of tissue include at least one of collagen, fat tissue and muscle.

35. The method of claim 1, further comprising varying a force profile of the tissue anchors based on the depth of the tissue with which the anchors engage.

36. The method of claim 1, further comprising varying a force profile of the tissue anchors over the perimeter of the filler material.

37. The method of claim 1, further comprising varying at least one of the length of the tissue anchors, the shape of the anchors, the materials of the anchors and the density of the anchors to vary a force profile over the interface between the wound closure device and the wound margin.

38. The method of claim 1, wherein the stabilizing structure is attached to the tissue anchors.